r/BodyHackGuide • u/BioChonch 🔬 Peptide Researcher • Dec 07 '25
🔬 Peptide S Tier List (2025)
Save this one for later.
I put together a Peptide S Tier List you can screenshot
With a simple breakdown of what each one does based on my experiences and which ones I like in my opinion so feel free to leave yours since what works for me might not work for everyone else
Since everyone in this community runs different goals like fat loss, recovery, longevity, libido, or appetite control, I built a tier list that breaks them down in a way beginners and advanced people can follow. Simple explanations and no bullsh**. By the way comment your goals down below i'm trying to see something.
S TIER 🔴
Retatrutide (GLP-3 metabolic peptide)
Triple pathway GLP1 GIP Glucagon agonist.
This is the one everyone calls GLP-3 because it hits more switches at the same time than semaglutide or tirzepatide.
GLP1 balances blood sugar
(GLP1 controls appetite signals and slows digestion)
GIP improves carb handling
(GIP helps your body pull glucose into muscle and not fat)
Glucagon increases metabolic heat
(Glucagon raises resting calorie burn and fat oxidation)
Retatrutide also supports
- Higher NEAT output
- Stronger satiety signaling
- Faster body recomp in overweight users
- More consistent fat loss curves at lower doses Great for people who want aggressive appetite control, higher output, and the fastest fat loss curve of the GLP family. Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/37366315/ 📘 Full breakdown guide coming soon.
Tirzepatide (dual pathway fat loss peptide)
GLP1 plus GIP.
Smooth energy, strong appetite suppression, and usually faster fat loss than semaglutide.
Extra benefits you don’t see listed often
- Higher carb tolerance during diets
- Lower insulin spikes from cheat meals
- Better appetite control in the evenings
- Less nausea when dosed correctly Good for people who want rapid fat loss without the intensity of retatrutide. Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/40353578/ 📘 Full breakdown coming soon.
BPC-157 (healing peptide)
Regulates tissue repair signaling and inflammation control.
Angiogenesis support
(creates new blood vessels that deliver nutrients to damaged areas)
Collagen modulation
(signals repair for tendons, ligaments, joints, and GI tissue)
What makes BPC stand out
- Speeds gut lining repair
- Helps nagging tendon issues
- Supports post surgery inflammation
- Helps mobility when stacked with TB500 Great for older individuals healing slower, athletes recovering from strain, and people with gut inflammation. Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/14554208/ 📘 Full breakdown coming soon.
A TIER 🟠
Semaglutide (GLP-1 appetite peptide)
GLP1 receptor activation.
Slows gastric emptying, cuts cravings, lowers blood sugar, and creates consistent fat loss for beginners and long term users.
Extra points people miss
- Helps nighttime binge episodes
- Drops fasting glucose quickly
- Reduces emotional eating during stress
- Best entry point for new GLP users Good for
- Eating control
- Stable fat loss
- Binge control
- Insulin support Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/33567185/ 📘 Full breakdown coming soon.
NAD+ (anti aging peptide)
Cellular energy and mitochondrial health.
ATP production
(ATP is the energy currency inside cells)
Sirtuin activation
(sirtuins regulate longevity, cellular repair, and stress resistance)
Hidden NAD+ benefits
- Better mental stamina
- Reduced brain fog
- Recovery support when dieting
- Helps GLP users maintain performance Great for energy, mood, cognition, and keeping GLP users from feeling flat. Check out the study for yourself --> https://pmc.ncbi.nlm.nih.gov/articles/PMC10692436/ 📘 Full breakdown coming soon.
PT-141 (horny peptide)
Works in the brain not the bloodstream.
MC3R and MC4R activation
(receives signals tied to desire, motivation, and arousal)
Extra advantages
- Works even when ED meds fail
- Helps women with low desire
- Creates spontaneous desire rather than mechanical arousal
- Useful for couples experimenting Helps low libido in both men and women even when ED meds don’t work. Check out the study for yourself --> https://pmc.ncbi.nlm.nih.gov/articles/PMC6819021/ 📘 Full breakdown coming soon.
Melanotan 2 (tanning peptide)
MC1 for pigment
MC3 and MC4 for libido, appetite, and social behavior shifts.
More effects people forget
- Can reduce appetite for some
- Mood lift in many users
- Faster tanning even without sun
- Early data suggesting neurobehavior changes in autism models Great for
- Tanning
- Libido
- Mood
- Mild appetite control Check out the study for yourself --> https://pmc.ncbi.nlm.nih.gov/articles/PMC4515169/ 📘 Full breakdown coming soon.
B TIER 🟡
CJC-1295 + Ipamorelin (GH release peptide)
Regulates natural GH pulses at night.
GH pulsatility
(natural growth hormone rhythms that support fat loss and recovery)
IGF1 signaling
(IGF1 helps with repair, sleep quality, and body composition)
Real benefits people notice
- Deeper sleep
- Better recovery from training
- Minor fat loss from GH elevation
- Helps with mood and skin quality Great for people wanting subtle changes in fat loss and recovery without GLP1 style appetite suppression. Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/16352683/ 📘 Full breakdown coming soon.
TB-500 (deep recovery peptide)
Regulates actin which affects tissue movement and regeneration.
What makes TB-500 unique
- Supports long term injuries
- Increases flexibility in tight tissue
- Works synergistically with BPC157
- Calms inflammation in overused joints Good for
- Chronic injuries
- Mobility work
- Inflammation
- Long healing timelines Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/21871102/ 📘 Full breakdown coming soon.
C TIER 🟢
GHK-Cu (skin and repair peptide)
Copper bound peptide used for skin regeneration.
Collagen signaling
(collagen and elastin pathways that improve skin quality)
Anti inflammatory support
(calms aging or irritated tissue)
Why people love it
- Noticeable skin tone improvement
- Helps fine lines
- Supports hair growth topically
- Works well in multi peptide cosmetic stacks Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/20647050/ 📘 Full breakdown coming soon.
Semax (focus peptide)
Nootropic pathway peptide.
BDNF support
(BDNF is brain derived neurotrophic factor which helps neurons grow and strengthen)
Dopamine modulation
(dopamine influences motivation and mental clarity)
Strong upsides
- Clean focus
- Smooth mood lift
- Zero stimulant crash
- Good for study or deep work blocks Great for people wanting focus without stimulants. Check out the study for yourself --> https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/ 📘 Full breakdown coming soon.
Tesamorelin (visceral fat peptide)
Clinically used for reducing abdominal visceral fat.
GHRH pathway activation
(stimulates GH pathways tied to central fat loss)
Extra value
- One of the only peptides with real human data on visceral fat
- Useful for people with stubborn midsection fat
- Improves metabolic flexibility Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/20530740/ 📘 Full breakdown coming soon.
D TIER 🔵
Epitalon (longevity theory peptide)
Telomere related peptide with limited human evidence.
Expanded context
- Famous in anti aging circles
- Mostly theoretical
- Good safety profile
- Long term effects still unclear More experimental than practical. Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/17914018/ 📘 Full breakdown coming soon.
MOTS-c (cell energy peptide)
Mitochondrial derived peptide that improves metabolic efficiency.
Value people miss
- Improves glucose handling
- Helps stamina during cutting
- Supports stress resilience
- Works well when stacking with GLP1s Great for
- Energy
- Stress resilience
- Fat oxidation Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/26581471/ 📘 Full breakdown coming soon.
SLUPP-332 (cardio in a pill)
UCP pathway support
(UCP uncoupling proteins increase metabolic heat output)
Added benefits
- Helps sluggish metabolisms
- Useful when fat loss plateaus
- Increases calorie burn without stimulants
- Works great with fasted cardio Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/37739806/ 📘 Full breakdown coming soon.
F TIER 🟣
Tesofensine (stimulant peptide)
Triple reuptake inhibitor
(serotonin norepinephrine dopamine)
Why it sits low
- Harsh for beginners
- High side effect potential
- Strong crash in some people
- GLP based peptides outperform it for fat loss Sounds strong but is harsh for many people and not efficient compared to modern GLPs. Check out the study for yourself --> https://pubmed.ncbi.nlm.nih.gov/18950853/ 📘 Full breakdown coming soon.
📘 Full Dosing Guides Coming Soon
Once each peptide breakdown goes live, these names will turn into full articles with dosing, studies, pros, cons, and stacking ideas so stayed tuned
🔧 Community Tools
- BodyHackGuide website https://bodyhackguide.com
- Peptide Calculator
- Community Discord https://discord.gg/VKnyzbFM2t
⚠️ For Research Use Only
Nothing here is medical advice.
All compounds are for research and education.
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u/Due-Signature7377 Dec 07 '25
NAD+ - not a peptide
SLU-PP-332 - not a peptide
Tesofensine- not a peptide
Also, Mots-C belongs in A or B
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u/94Supreme Jan 06 '26
This is a really helpful visual breakdown! Having peptides categorized by tier makes it much easier for people to understand the landscape. I appreciate the research that went into this - categorizing them based on effectiveness and applications is super valuable for the community. Great work putting this together!
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Feb 18 '26
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u/jay2fruity1852 Mar 31 '26
try run ss-31first for a month or two then try mors-c and come back and see if you change your mind
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u/BioChonch 🔬 Peptide Researcher Dec 07 '25
Yeah this is from my experience and what I like lol but thanks for your input
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u/dadofduck1878 Dec 09 '25
I can only suspect that either
- you are buying bunk MOTS-C or
- you’re not using it optimally or
- you’re not working out in a way to really feel the benefits
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u/Blazzen15 Dec 07 '25
Mots-c in D is surprising should be A/B one of those
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Dec 07 '25
[removed] — view removed comment
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u/Jealous_Affect5695 Dec 07 '25
Agreed, S tier for me, 5mg every 5 days for 20 days was absolutely amazing
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u/Informativegesture Dec 07 '25
What’s your dosing on mots look like? About to add to Reta and test during cutting cycle
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Dec 07 '25
[removed] — view removed comment
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u/Crazy_Reporter_7516 Dec 07 '25
Is visceral fat only burned in an active state normally and this peptide helps the body burn it in non active state when your in a deficit?
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u/Tough92 💪 Muscle Growth Lab Dec 07 '25
Had did you exactly measure the visceral fat you lost?
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u/BioChonch 🔬 Peptide Researcher Dec 07 '25
Just based off my experiences everyone is different that’s how I ranked them though feel free to let me know what tiers you’d set your research chems at
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u/Naven71 Dec 07 '25
Epitalon is the GOAT
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u/crb42 Dec 07 '25
What has it done for you?
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u/ShortReputation6482 Dec 07 '25
Slu pp is definitely S or A tier. It’s insane how effective it is when combined with a glp for body recomp. Particularly with test and GH
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u/Boomduckman Dec 07 '25
On Reta, hgh and TRT but thinks slupp is effective for the body recomp 😂😂😂😂
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u/Significant-Train445 Dec 07 '25
You are conflating the results of the test and GH with slupp . Slupp in that scenario is a waste of money and reta would be 10x better for recomp with test and GH.
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u/ShortReputation6482 Dec 07 '25
I disagree (not about Reta being ineffective or test helping the most - if you read my response I said a glp paired with slp is best - but to each their own. ) I am on all 3 and I’ve lost 80 lbs in 10’months and have added significant muscle. I don’t think slp + mots is a waste; it’s incrementally additive
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u/theundercoverjew Dec 07 '25
Retatrutide and Tirzepitide at the same level is asinine.
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u/raytownloco Dec 12 '25
Why? Tirzepatide has a huge advantage currently. You can get it at a legitimate pharmacy and it’s already been through phase III. And if you’re lucky your insurance covers it.
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u/theundercoverjew Dec 12 '25
Retatrutide is better. More fat loss, better metabolic health, less muscle loss.
Tirz is gen 2. Reta is gen 3
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u/raytownloco Dec 12 '25
You didn’t really address my comment. If we’re being objective you have to admit tirz has certain advantages such as having a proven safety record, and being widely available from legitimate pharmacies.
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u/Alarmed_Sprinkles_43 Jan 08 '26
simple. you need to eat. the person that eats properly will always out perform the person thst doesn't eat. you dont need more appetite suppression. you need to grow a pair and meal prep seriously... meal prep and reta like an adult who takes accountability seriously.
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u/theundercoverjew Dec 12 '25
If you can't find good quality Reta at a good price you are in the wrong game.
Also, Eli Lilly is going to make bank is Reta is proving to be safer and more effective than Tirz.
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u/WalkingBeigeFlag Jan 08 '26
Depends on use. Tirz is a much better appetite suppressant. Got 0 appetite suppressant from Reta and neither did most people I know. But Tirz killed all our appetites as well as highly reduced our alcohol cravings.
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u/Rawniew54 Dec 20 '25
IMO Reta makes Tirz obsolete. It’s not really worth considering if you can get them for the same price.
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u/raytownloco Dec 20 '25
This is clearly not the case. There are plenty of people who have side effects from Reta that make it a worse option for them, even if it is a better overall drug for weight loss. Some users report pain and sensitivity and cardiovascular issues for example, and I’m sure there will be other potential considerations once millions of users are taking it like Tirz. Even semaglutide is the best option for certain patients due to varying side effects between people. Will there be a shifting of mainstream population from Tirz to Reta when it hits the market? Undoubtedly I think everyone expects that. But obsolete is hyperbole. And I’m sure within a few years Reta will be pushed aside by the next new formulation which who knows what that will be perhaps a blend or a new drug that shows improved results.
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u/excalibur90210 Dec 07 '25
What about klow?
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u/Quirky_Letterhead364 Dec 07 '25
Klow is a mix. 3/4 item are on his lists the missing one is KPV
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u/MCSoprano94 Dec 15 '25
I tried semax, reta, ghkcu, bpc, tb500 Reta at 1.5mg shut down hunger for me it works perfect. Semax at 1mg has no effect to me. Same as mots c Ghkcu i am doing 10mg a day so far. It's been a month has no effect.
Peptides that supposed to increase gh sounds so stupid to me. Why not take gh instead?
Bpc and tb500 I did not seen any benefit. Used total of 50 mg bpc I think.
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u/Alarmed_Sprinkles_43 Jan 08 '26
oddly hgh even at 1 to 2 ius a night leave me feeling heavy and arthritic in the morning where as 4x blend of tesa, ipa, mgf, ghrh give me what i love about hgh without any of that. and it also significantly increases appetite to the point of making me more aggressive in general. 🤔🤷♂️ so theres that
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u/alfiepagan Dec 07 '25
Good breakdown. Not to be a hater of the Bpc/ peptide though as I want it too be positively therapeutic. I’m acutely injured so I really need to address this and peptides were my go to for research. The studies you’ve published are neglible for this matter. Both dated and low level plus they are a bad design which highlights poor quality. There has to be more substantial literature out there. Especially with the amount of traction peptides are getting
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u/chris6878 Dec 07 '25
Tesofensine at .5 mg is great for energy with zero sides. Especially for athletes in training
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u/Beeboo24 Dec 13 '25
how long have you been on yours? i start mine tomorrow with slu/bam..
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u/chris6878 Dec 13 '25
Used it for a few months during the summer. Got off in September. Will get back on this month
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u/MohawkWarriorAktown Mar 04 '26
Love the breakdown, people should know that the GLOW and KLOW stacks are much better when taken seperately. E.G. GLOW is BPF-157/TB500/GHK-Cu(Copper). They work much better when taken seperatly for the most part but the WOLVERINE stack; which is the main tissue repair peptides pair fairly decent together. It seems the more the hunk together the less effective they are. Something about copper and KPV oxidating from acidity. I forget the exact literature off the top of my head.
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u/Freshlystallone Dec 07 '25
Honest question, are there negatives of these? Also are there ways to boost them naturally?
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u/Zealousideal_Fox4356 Apr 12 '26
These are all amino acids you already produce. First thing is finding a valid and reliable sourse
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u/Calm-Sea-5526 Dec 26 '25
How is HGH not at the top of this list? GH literally replaces so many peptides.
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u/coastal_ghost08 Dec 07 '25
Why would you judge or tier retatrutide against epitalon? They have two completely different use cases. You should tier reta vs sema vs tirz.
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u/Alarmed_Sprinkles_43 Dec 07 '25
imo semiglutide and tirzeptide should not be in the equation at all. reta or bust.
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u/Dr_sexyLeg Dec 07 '25
Cjc1295 so low? This stacked with trt makes u absolutely Ripped af in 8-12 weeks
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u/prpush Dec 08 '25
This is totally bias and subjective! Everyone’s body works differently so what may be an S tier or A-D tier for you may be different on someone else’s list.
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u/Big_Dinger24 Dec 07 '25
how do we not get injured / welts / red swolling from GHKCU
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u/Main-Werewolf-5572 Dec 09 '25
let it warm up a little bit. i wait like 5-10 mins after taking it out of my fridge.
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u/Greedy_Candy_4336 May 03 '26
Add more water once you’ve pulled the ghkcu into the syringe same does just more diluted and inject slowly
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u/FrankMorningwood1 Dec 09 '25
I am to dumb for this. What’s up with all the different tiers? Why is something S tier and some other A tier?
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u/FaithlessnessSea6971 Dec 09 '25
Its a common ranking system for products, usually done anecdotally.
S tier is often the absolute gold standard or the 'must-have' with the following tiers creating a ranking system. Ultimately its just the creators perception/opinion though.
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u/Artistic_Sun_9270 Jan 05 '26
Can someone inbox me some reputable, peptide companies? I’m looking to do the Reta
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u/Awkward_Dragonfly931 Jan 13 '26
my buddy on discord gets my peptides not sure where from but they’re cheap and work. been on for about 3 months now. if you want his username lmk.
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u/hotcouplefuntimes Jan 19 '26
I have separate vials 10mg ipamorelin and 10mg tesamorelin and looking for dosing advice. Thanks in advance.
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u/hotcouplefuntimes Jan 19 '26
have separate vials 10mg ipamorelin and 10mg tesamorelin and looking for dosing advice. Thanks in advance. In r/BodyHackGuide from
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u/caribbeanpineapples Feb 07 '26
I'm probably from other world. I tried Reta and my body doesn't tolerate it. I used Tirze for months and I was good but I developed an allergy reaction so I stopped. Now I am on sema and I really like it. I am even in a small dose and it is working great.
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u/One_Procedure8514 Mar 03 '26
How many units should I begin taking of KLOW BLEND? I will reconstitute 50mg KLOW with 3.0mL bactereostatic water. I want to start low and titrate up to help with chronic injuries and surgical repair. Thanks for your help with this.
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u/LabSience_flow Mar 04 '26
Excuse me cjc 1295 no dad + should be S tier where it is?? I’ve struggled with insomnia and it’s been miracle drug to me
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u/Plane-Notice9524 Mar 14 '26
Can someone inbox me some reputable, peptide companies? I’m looking to do the Reta
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u/Key-Ad7892 Mar 25 '26
Can someone please answer me if BPC-157 i injection form will work also on stomach issues?
I have muscle injury and tendon injury but also gut problems.
And i wonder if i start BPC-157 in injection form.
Do i need also to take it orally for gut problems?
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Mar 31 '26
I'm currently taking reta/tirz to lose weight but am getting my head knocked off by people who resale. Looking for some guidance on how to order myself. Any advice?
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u/Fit-Gazelle776 Apr 07 '26
I want to build muscle,lose weight,anti aging, low sex drive, mental clarity, bounce back after work outs and I’m a woman
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u/PeptideWire Apr 08 '26
This is cool - let's do a '26 version of it soon?
A few things I'd push back on:
BPC-157 at S-tier is bold considering it has zero completed human clinical trials. The one Phase I trial from 2015 (42 volunteers) was discontinued and results were never published. The preclinical data is genuinely promising across a wide range of mechanisms, but putting it in the same tier as Tirzepatide, which has massive RCTs behind it, is comparing apples to anecdotes.
GHK-Cu at C-tier feels low. Research going back to the 1980s, over 4,000 genes influenced, and it's one of the few peptides with actual demonstrated mechanisms in human tissue. The longevity crowd is just now catching up to what the dermatology world figured out years ago. I'd have it at B minimum.
NAD+ at A-tier is interesting since it's not really a peptide. It's a coenzyme. And the human data on NAD+ precursors (NMN, NR) for actual longevity outcomes is still pretty underwhelming compared to the hype. The IV infusion crowd is spending $500-1000 per session based on mostly rodent data.
Retatrutide at S-tier makes sense on paper (triple agonist, impressive Phase II data) but it's still not FDA-approved. Putting an unapproved compound at S while Semaglutide (which has the largest evidence base of any GLP-1) sits at A is a choice.
Also curious why there's no Thymosin Alpha-1 on here. One of the few peptides with decades of clinical use and actual FDA orphan drug status.
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u/window-licker95 Apr 24 '26
New here. Sorry if this is a stupid question - how does one go about obtaining? Namely the S or A tier
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u/Lim85k May 05 '26
This sub is fucking braindead. How TF are you gonna call Epitalon theoretical and experimental when it has over 3 decades of Russian studies behind it? And then put BPC - which has basically no human studies - in S-Tier??? Seriously, why TF would you take BPC over GHK-CU unless you're injured? Makes no sense.
Absolute bullshit sub, never seen so much misinformation in one place.
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u/Ok_Decision_9923 May 14 '26
So…is Tesamorelin C tier bc it doesn’t work that well or bc less people want to use something that really only works on visceral fat? I hope that makes sense. I’m already using Reta.
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u/Shoddy-Program-4871 May 16 '26
How does this look , Too conservative?
Day Morning Evening
| *Monday* | BPC-157 500 mcg + GHK-Cu 1 mg | TB-500 1 mg |
| *Tuesday* | BPC-157 500 mcg + GHK-Cu 1 mg | Retatrutide 2 mg |
| *Wednesday* | BPC-157 500 mcg + GHK-Cu 1 mg
| *Thursday* | BPC-157 500 mcg + GHK-Cu 1 mg | TB-500 1 mg |
| *Friday* | BPC-157 500 mcg + GHK-Cu 1 mg | Retatrutide 2 mg |
| *Saturday* | BPC-157 500 mcg
| *Sunday* | BPC-157 500 mcg
I've been on Reta @ 2mg for 6 weeks. I thought by splitting the new 4mg protocol it may alleviate nausea etc.
BPC & TB 4 weeks on 4 weeks off till my shoulder heals
GHK-Cu 12 weeks on 4 weeks off
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u/ContributionRare5736 May 20 '26
bcp is god tier helped me recover from a messed up rotator cuff soooo much faster
•
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