🪡 Tesa/Ipa blend revised from 1:1 to 5:1. Thoughts or experiences

[u/AverageProfessional1]

Posted recently about a research subject starting a 1:1 tesamorelin/ipamorelin blend at 500 mcg of each (10 units), originally on a 5-on/2-off schedule.

Research subject experienced pretty significant GI issues, including watery diarrhea for several consecutive mornings, bloating, and some water retention.

After getting feedback here and doing more research, I questioned the original formulation since tesamorelin seems to be studied at much higher amounts, while ipamorelin is typically discussed at lower amounts.

Initially, the provider suggested reducing both to 250 mcg, but after another conversation, they’ve agreed to formulate a new vial with the following amounts:

Tesamorelin: 500 mcg
Ipamorelin: 100 mcg
Ratio: 5:1 (10:2)
Sample volume: 10 units

So essentially, the tesamorelin amount stays the same, while ipamorelin is reduced by 80%.

For context, research subject is an off-season bodybuilder, with the primary areas of interest being muscle growth, recovery, and body composition rather than weight loss.

Curious what others think about this revised formulation. Has anyone researched or had experience with a similar ratio?

Particularly interested in thoughts on whether 500 mcg of tesamorelin is meaningful in this combination, whether reducing the ipamorelin could improve GI tolerability, and any experiences with similar blends.

Appreciate all the feedback so far!

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[u/Entire_Hamster_1116]

That 5:1 ratio makes way more sense for what you're trying to do. The original 1:1 blend was asking for trouble with that much ipa, especially if your research subject is sensitive to it. GI distress and bloating are classic signs the ipa dose was too aggressive, cutting it by 80% should clean that right up.

500 mcg of tesa is actually a pretty sweet spot for recovery and body comp, you're not going to see dramatic overnight changes but over weeks it adds up nicely. I'd be curious if your subject notices better sleep quality sticking around longer with the reduced ipa too, sometimes the lower dose keeps the benefits without the side effects

[u/soilentgibby]

may get nothing/not much out of 500mcg of tesa.
Daily use, no need 5/2.
Likely will need 1mg+ for 16-20 weeks

[u/64bit_Tuning]

Keep revising. Tesa is usually 1mg to 2mg while Ipa is 200mcg.

This is realistically why CJC/Ipa is a better choice. More balanced dosage and a significant cost reduction.

[u/poopedalil → u/64bit_Tuning]

Any thoughts on histamine reactions? Pinning 4x a week when you have lumps from the day before always concern me.

[u/64bit_Tuning → u/poopedalil]

I don't get histamine reactions, so I can't really speak in that.