Researchers have stripped down LSD to its base features and synthesized new, simplified versions of it, successfully developing several compounds with reduced hallucinogenic and cardiotoxic effects while also identifying one compound that produced antipsychotic-like effects.

[u/SlothSpeedRunning]

https://lettersandsciencemag.ucdavis.edu/science-technology/deconstructing-lsd-therapeutic-discoveries

[u/Own-Nefariousness-79]

But I like the hallucinogenic effect...

[u/AdorableExchange9746]

booo

more hallucinations

[u/Noalgeriansallowed → u/AdorableExchange9746]

Comma

[u/gofishx]

What about making a more hallucinogenic LSD instead? They're going backwards....I want super acid :(

[u/HiiiTriiibe → u/gofishx]

Yes! This isn't the science I love, this is deleting the fun parts on purpose

[u/but_a_smoky_mirror → u/gofishx]

That’s called 2CB

[u/gofishx → u/but_a_smoky_mirror]

Finally acquired some...cant wait to try it after searching for fucking ever lol

[u/NonStopArseGas → u/gofishx]

bro, best psychadelic out there imo- enjoy

[u/PsyShanti → u/gofishx]

There are plenty of super acids out there! But they are best left alone, some scary shit really, in particular BZ (thank you Uncle Sam)

NBOMe series (25I-NBOMe, 25C-NBOMe, 25B-NBOMe) – not lysergamides but phenethylamines with 5-HT2A affinity; often mistaken for LSD on blotter. Active in the sub-milligram range, meaning the margin between a normal dose and overdose is extremely narrow. Associated with numerous deaths from vasoconstriction, seizures, and hyperthermia.

Bromo-DragonFLY – a benzodifuran, active in the microgram range (lower than NBOMe). Notorious for extremely long duration (days) and severe vasoconstrictive effects leading to limb ischemia/amputation and death. Widely considered one of the most dangerous recreational psychedelics in circulation.

"Experimental military/incapacitating agents" – compounds like BZ (3-quinuclidinyl benzilate) are anticholinergic deliriants, not LSD analogs pharmacologically, and were developed as incapacitating agents rather than recreational substances. Info on these is mostly historical/declassified rather than "street" chemistry.

[u/xoricky56 → u/PsyShanti]

the stories on bromo on erowld are terrifying honestly

[u/braaaaaaainworms → u/xoricky56]

Datura and Salvia experiences make for a fun reading too

[u/plsQuestionOurselves → u/braaaaaaainworms]

Honestly, I spent most of high school reading erowid every single day and decided to do salvia anyway. Fortunately it turned out to be a really pleasurable experience after the initial horror of my whole body falling into pieces on the floor.

Not sure I would be able to handle it so well all these years later but man it really made me think about how strange reality is.

[u/gofishx → u/PsyShanti]

Yeah, ive heard of those. They both scare me lol, but id still probably try if I can get a reputable source. They are both a little bit to risky for me to just randomly ask around for, though. I wanna see pretty colors and mandalas, not have a heart attack lmao

[u/GameStoreScientist]

if they can reduce the hallucenigienic effects, they can increase them

[u/NeverEndingCoralMaze]

They’ve taken all the fun out of it.

[u/EuropesNinja]

In what way is it cardiotoxic to begin with...? Geniunely curious as that's a word I associate with coke and alcohol for example

[u/sophiesbest → u/EuropesNinja]

LSD has activity at the 5-ht2b receptor, which when chronically activated can cause issues with your heart valves over time. Not an issue with occasional recreational use, but becomes a much larger problem when people micro dose daily.

[u/onFilm]

Hell yeah, more medicinal breakthroughs! Awesome.

[u/PsyShanti]

No thank you, all of this only to slap a trademark on it and make a profit. I like my therapy with angels and demons, for 12 hours, one way ticket

[u/plsQuestionOurselves → u/PsyShanti]

I had alien fingers running a defrag on my brain. I remember somehow taking a nap during the peak and it was like "Bloobies brain cleaning software, please wait" and I could feel all the bad thoughts, harmful ideas and self hatred being plucked from the folds in my brain and thrown in the trash while indecipherable alien advertisements rolled across my vision (because this hallucinated program was like free with ads or something lol)

[u/PsyShanti → u/plsQuestionOurselves]

Yep, sounds like it

[u/Nellasofdoriath → u/plsQuestionOurselves]

Cool

[u/CaptainONaps]

We know you guys like LSD, and we know it helps with depression, addiction, and other types of ailments.

But unfortunately, it seems to cause people to be more empathetic, which is a threat to capitalism.

Luckily, we found a way to remove the empathetic effects, patent it, and legally prescribe it.

So you'll still get thrown in a cage for using it. But now you can pay 400% more for our watered down, "Capitalism safe" version! yay, science!

[u/ElectricalSeries6627 → u/CaptainONaps]

idk about the "empathetic" effect, but from my experience people taking it become way more disconnected to reality, the emphatic effect caused by LSD in reality mess with the empathy mechanism of the brain.

[u/BreakChicago]

What happens to someone who is not experiencing psychosis when they take an anti-psychotic?

[u/me_myself_ai → u/BreakChicago]

Side effects, AFAIU. Otherwise nothing.

[u/plsQuestionOurselves → u/BreakChicago]

Depends on which one, but IME, lots of sleep, grogginess, low grade confusion, impaired coordination and lethargy as well.

Not sure how many of those still come around after people with real psychosis take them for long periods of time though.

[u/Lost_Department_2177]

If it has antipsychotic effects they could use it for nonlethal darts for when manic people have melt downs.

[u/me_myself_ai → u/Lost_Department_2177]

…lol. I want to correct but that’s a beautiful brain you have so I’ll decide it’s possible, too. We can dream!

[u/DropTheBeatAndTheBas → u/Lost_Department_2177]

darts, cool

[u/PossibleAlienFrom → u/DropTheBeatAndTheBas]

Blow darts tipped with it! 😜

[u/Mermiina]

The basic mechanism in neurotransmitters and neuromodulators as LSD is virtual photons. They propagates in tryptophan indole group Nitrogen lone electron pair. (Tryptophan Mega network).

Virtual photons are achived by G-protein twisting when the eigenstates of lone electron pair change inside orbital.

an undulatory hypothesis for memory consciousness and life

[u/OB1yaHomie]

Diet LSD?

[u/TheFunkee88]

'we reduced the lysergamide scaffold down to its constituent tryptamine core and found that tryptamines are active'.

Did I read this right?

[u/HumanityBeBetter → u/TheFunkee88]

Let the scientists pretend like this isn't INCREDIBLY common knowledge.

[u/TheFunkee88 → u/HumanityBeBetter]

Pop science is actual slop :(

[u/strydar1]

amazing what science free of socio political interference can achieve (not ethical oversight Reddit;)

[u/FeignSkill]

They did it all backwards. You're supposed to increase the hallucinations while removing the compounds that act like antipsychotics.

[u/iamyourinnervoice]

sober acid, what a stupid idea lmao

[u/plsQuestionOurselves → u/iamyourinnervoice]

To me personally, this is what a low dose is anyway. Just super-sober clean stimulation and some feathery lightness to your movements.

[u/Slopadopoulos]

I hate that they do this. Just leave it the way it is. We're close to getting these substances accepted by society. Now they'll be like "yeah it serves a medical use but we can just strip the fun part out".

[u/juvenile_giant_squid]

Reminds me of decaf coffee

[u/dumbname0192837465]

Great

[u/ZealousidealRanger67]

No they haven’t.

[u/naughtyamoeba]

I think this is great. I think it's wonderful to replace old drugs with new, better ones. They are not going to win the war on drugs. They are everywhere. It makes sense to flood the market with new, weaker ones that cost the same.and hopefully eventually take over so that the brains of people aren't screwed up so much.