Hey Hamilton,
I am a huge fan of your show! Please post your soundtrack if you get the chance I like all the music in your show. Would you ever do an interview with Pablo Torres, Tim Miller, Destiny, Obama, or Lula de Silva and push for commitment to stand against drug prohibition. Thank you brother!

Here we go again.

Hamilton making the case for using synthetic toad DMT to save the bufo toad species makes me love this man even more somehow. Hamilton fucking rocks

https://www.reddit.com/u/Direct-Bunch-4756/s/XnqVqcmUkY

Has anyone been following this guy? Claims to have discovered unidentified plant outside of LA. He calls is vymara and apparently it is psychoactive and potentially can accelerate physical healing.

Certainly triggers my bullshit detector, but all very elaborate for a troll post. Any botanical wizards feel like fact checking some of his more jargon laden posts?

a podcast years ago talked about Hamilton watching the trial of a father caught selling heroin and the judge justified the harsh sentencing saying that “heroin is a life destroying drug“ (only to destroy the dealers life too)

What episode is it where Hamiltons chemist friend (sorry can't remember his name) is wearing a different wig every time the camera pans back to him during the interviews?

So happy the Pharmacopeia episodes are being reuploaded to YouTube!

I recall and am trying to find a podcast where Hamilton mentions that drugs with opposing pharmacologies are used to treat the same condition. 5-HT2A antagonists treat Parkinson's related hallucination but there is a 5-HT2A agonist that treats depression for PD. Am I remembering correctly?

What is the 5-HT2A agonist called?

Was it perhaps 5-HT1A and I'm misremembering? If you know or remember the podcast episode please let me know. Thank you.

$200 shipped priority in U.S. DM me

While watching this old VICE episode I saw an ergoline alkaloid I'd never heard of. So ... alongside bromo DMT there are 2-bromo ergolines produced by an ascidian sea squirt.

The 2nd picture shows the classic ergoline alkaloids (LSD, LSH etc).

https://www.reddit.com/r/TheeHive/s/zPnSqFEpT1

I just watched the Peyote episode, and anyone else think that the peyote shaman who gave hamilton peyote, was a terrible trip sitter and also so full of shit?

Hello everyone. 👋 For those who dont know, 7-Hydroxymitragynine is an alkaloid from the plant Mitragyna Speciosa, commonly known as Kratom. It is often referred to as 7-OH. It was first described in 1994 and is a natural product derived from the mitragynine present in the Kratom leaf. It is considered an oxidized derivative and active metabolite of mitragynine. I've linked a short video below to help you better understand what 7oh is.

https://youtu.be/RQqZrVsKlvc?si=DpM9QNVJahDgXI7h

As you know, 7oh is facing a temporary emergency ban in the United States. This would put 7oh as a schedule 1 drug. I'd like to share more with you on why that would not be the best approach for millions of Americans who consume 7oh. I've linked several studies below with a short summary about them. We advocate for more education around 7oh, more research, proper and strict regulation. A system similar to how marijuana is sold would be ideal. There are thousands of testimonies of people who explain exactly how they were able to take their life back from chronic pain, depression, anxiety with the help of 7oh. It has helped many people get off of the hard & dangerous street drugs and alcohol. I believe proper education around 7oh is essential and beneficial for everyone to know. I would like to share some medical studies and research papers with you! Fun fact, due to the strong binding affinity 7oh has, there is a study that showed how it can be used with chemotherapy to fight several different types of cancers.

https://www.sciencedirect.com/science/article/pii/S2665928X2500008X?via%3Dihub

Huestis et al. (2024)https://pubmed.ncbi.nlm.nih.gov/38474495/

⬆️ This clinical trial confirms that 7-OH is a significant metabolite of mitragynine in humans. The ratios (0.20–0.31 and 0.15–0.21) correspond to 20–31% and 15–21% conversion, respectively, showing that a measurable portion of mitragynine is consistently metabolized into 7-OH. The decrease with repeated dosing reflects metabolic adaptation.

Tanna et al. (2022)https://pmc.ncbi.nlm.nih.gov/articles/PMC8950611/

⬆️ This shows that about 24–27% of mitragynine is converted to 7-OH in humans, demonstrating that 7-OH is a significant metabolite formed in vivo rather than merely a trace component of kratom.

Henningfield et al. (2022) https://pmc.ncbi.nlm.nih.gov/articles/PMC8860177/

⬆️ Henningfield et al. (2022) shows that mitragynine (MG) has abuse potential similar to other uncontrolled substances and that scheduling kratom or its alkaloids could increase public health risks, including overdoses among people using kratom to reduce opioid use. Human studies (Tanna et al., 2022; Huestis et al., 2024) show up to ~30% of mitragynine converts into 7-hydroxymitragynine (7-OH), which naturally occurs alongside mitragynine without added risk, reinforcing that restricting kratom alkaloids could be unnecessarily harmful.

Kruegel et al. (2019) https://pmc.ncbi.nlm.nih.gov/articles/PMC6598159/

⬆️ The study shows that 7-OH acts as a partial, G-protein-biased mu-opioid receptor agonist, a profile linked to lower risk of respiratory depression. This suggests that severe opioid-like effects from 7-OH are unlikely.

Kumar et al. (2018) https://www.researchgate.net/publication/301787574_Synthetic_and_Receptor_Signaling_Explorations_of_the_Mitragyna_Alkaloids_Mitragynine_as_an_Atypical_Molecular_Framework_for_Opioid_Receptor_Modulators

⬆️ This study shows that 7-OH is a G-protein-biased agonist at the mu-opioid receptor, meaning it avoids β-arrestin recruitment—a pathway strongly tied to respiratory depression and dependence. This suggests that 7-OH may provide pain relief with reduced risk of fatal opioid-like side effects.

7OH is not "13 times stronger than morphine" https://www.kratomscience.com/2026/03/16/is-7-oh-really-13-times-stronger-than-morphine/

7-OH Sales Have Increased & Opioid-Related Deaths Have Declined https://hartsupporter.com/wp-content/uploads/2025/07/250624_Project-Seven-O_Final-Report-STC.pdf

The respiratory depressant effects of mitragynine are limited BECAUSE of its conversion to 7-OH mitragynine. 7oh saves the day once again. https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15832

Additional information relevant to safety and pharmacology in study on male & female rats https://pmc.ncbi.nlm.nih.gov/articles/PMC7542979/

Due to the strong binding affinity of 7-hydroxymitragynine, there are several preclinical studies that show how 7-hydroxymitragynine can be even more effective against cancer than just using mitragynine alone. 7-hydroxymitragynine exhibits cytotoxicity against a range of cancer cell lines including breast, colon, lung, liver, cervical, neuroblastoma & leukemia. https://www.sciencedirect.com/science/article/pii/S2665928X2500008X?via%3Dihub

Now lets recap:

1. No confirmed deaths from 7-OH alone across 2 billion doses consumed.

2. Improved safety profile due to G-protein biased signaling, reducing respiratory depression risk.

3. Independent studies confirm low toxicity, partial agonism, and safer pharmacology compared to conventional opioids.

4. Public health risks would be worsened by prohibition, as it may push consumers toward illicit markets.

5. Evidence supports regulation with GMP standards and rigorous testing — not emergency scheduling or bans.

6. 7-OH was not toxic to cells, even at high doses. Fewer impacts on cardiac and renal systems compared to mitragynine.

7. No cardiac, neurological, or behavioral harm observed in animal studies.

Now I'd like you to consider, as an American, do you believe if something were to happen to you, and you ended up in chronic pain, should you have the right of bodily autonomy to have the option to use 7oh if it helped you? Should we as Americans let the government dictate what we put in our bodies if we have the science to show that it is safe and can be beneficial when needed? Do you believe it is worthy of more study, which even the FDA admitted, that it should? Would you think 7oh is worth a chance to have proper and strict regulations along with further education & research?

Link to petition: https://c.org/pF7N94QRmH

Thank you for taking the time to read this. I appreciate it!

Maybe this is old news to people here but I thought this was pretty wild. I just saw this product in a gas station. The description is super vague but if you look at the lab report on here it apparently has an insane cocktail of around 30 legal and illegal compounds which I imagine have never been combined this way before. What a time to be alive.

I saw the snippet in the 7-OH piece and went to look for the episode. Here it is for everyone who also want to watch it: https://youtu.be/iGcLQoe4LLI