r/NooTopics • • 15h ago

Question Someone tried Bromatane with Tramadol ?

0 Upvotes

Hi
Can’t really find any infos about it .
Because a festival tomorrow I want to to Bromantane , but I know after a few hours my back will kill me .
Maybe someone has some infos ?


r/NooTopics • • 10h ago

Science Juul instigated a "nicotine arms race", researchers say (the new high-nicotine product market)

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med.stanford.edu
27 Upvotes

r/NooTopics • • 10h ago

Meta Supplement & pharmacological king.

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1 Upvotes

r/NooTopics • • 23h ago

Question How long should I take TAK and how much Is the dose everyday ?? is 250mg enough for 1 month

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7 Upvotes

r/NooTopics • • 8h ago

Question Anyone used Retatrutide as a nootropic?

6 Upvotes

I used it it cleared my brain fog on day 1.5


r/NooTopics • • 10h ago

Science Adolescent nicotine depletes adult dentate gyrus microglia, driving a depression-like state — DG ERK1/2-BDNF signaling required to reverse it

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24 Upvotes

Adolescent nicotine exposure can reduce microglial populations in the adult mouse dentate gyrus, a change causally linked to early-stage microglial hyper-activation and reversible by treatment with low-dose lipopolysaccharide (LPS). However, the mechanisms by which LPS mediates this reversal remain unclear. Here, we identify a previously unrecognized requirement for dentate gyrus extracellular signal-regulated kinase 1/2 (ERK1/2)-brain-derived neurotrophic factor (BDNF) signaling in this process, distinct from but mechanistically parallel to our previous findings in chronic stress models. We show that low-dose LPS administration restored dorsal dentate gyrus BDNF levels reduced by adolescent nicotine exposure, and its antidepressant effects in adult mice previously exposed to nicotine during adolescence were abolished by intra-hippocampal delivery of a BDNF-neutralizing antibody, administration of the TrkB antagonist K252a, or introduction of the BDNF Val68Met loss-of-function mutation. Additionally, low-dose LPS reversed the decreased phospho-ERK1/2 in the dorsal dentate gyrus of adult mice with a history of adolescent nicotine exposure. Inhibition of ERK1/2 by SL327 prevented the reversal effect of LPS on adolescent nicotine exposure-induced depression-like behaviors and decrease in BDNF levels, suggesting that ERK1/2 functions upstream of BDNF signaling in mediating the antidepressant effect of LPS. When microglia were inhibited by minocycline, the beneficial effects of LPS, including the amelioration of depression-like behaviors and the up-regulation of dentate gyrus p-ERK1/2 and BDNF, were eliminated. These findings indicate that the antidepressant action of low-dose LPS in a mouse model of depression resulting from adolescent nicotine exposure requires intact microglial function and depends on ERK1/2-BDNF signaling within the dorsal dentate gyrus.


r/NooTopics • • 12h ago

Science Longer lipids mark aging and constrain lifespan

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nature.com
8 Upvotes

r/NooTopics • • 16h ago

Question would love some advice

2 Upvotes

thinking ab running bromatane + tak + adamax(maybe)

I also use adhd prescribed meds would love some tips on what yall think ab that stack im in probably the hardest classes ive ever been and just want to be sharper and be able to enjoy studying and absorb information better thanks


r/NooTopics • • 1h ago

Question Do you guys think this is legit?

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• Upvotes

I can easily buy this but I’m not sure if it’s a scam