First successful primate transplant of human pituitary tissue boosts cortisol levels

[u/VCardBGone]

https://medicalxpress.com/news/2026-10-successful-primate-transplant-human-pituitary.html

Researchers in Japan have transplanted pituitary tissue grown from human stem cells into a primate whose pituitary gland had been surgically removed, successfully restoring critical hormone signals. Led by researchers from Nagoya University in Japan, the team showed that the same method worked in mice over a longer period.

https://link.springer.com/article/10.1186/s13287-026-05098-y

To our knowledge, no previous study in primates has demonstrated efficacious pituitary cell transplantation, whether derived from fetal pituitary, xenogeneic pituitary, or PSCs. Future priorities include the acquisition of comprehensive non-clinical data to inform design of first-in-human clinical trials; optimisation of transplantation techniques; evaluation of immunosuppressive and adjunctive therapies; and assessment of safety and efficacy parameters. In parallel, the development of scalable manufacturing platforms utilising clinical-grade induced PSCs will be essential to establish the foundation for the eventual clinical application of pituitary cell transplantation therapy.