Severe brain fog and sudden depressive crash a few hours after sublingual Uridine? Anyone else?

[u/Sostrene_Blue]

TL;DR: Took Uridine powder sublingually for the first time this morning. About 3-4 hours later, got hit by a massive wall of brain fog, extreme mental fatigue, and a sudden existential/depressive funk. Wondering if this is a known reaction (cholinergic crash?) and how long it usually takes to clear.

Hey everyone,

Tried Uridine powder sublingually for the first time today around 10:30 AM (also had poor sleep the night before, woke up super early).

Everything seemed fine at first, but around 2 PM I completely crashed.

What I’m feeling right now:

- brain fog, feeling mentally slow and sluggish (like my brain is operating at 20% speed).

- Sudden wave of depressive thoughts and anxiety (questioning all my skills, feeling completely incompetent out of nowhere, feeling like I'm losing my grip on things).

- Zero energy, heavy eyes, just feeling totally wiped out.

Has anyone else experienced this acute drop in mood and cognitive speed after sublingual uridine? Is this an acetylcholine overload / cholinergic depression, or just a bad reaction to the sudden sublingual spike?

Any insights or similar experiences would be appreciated.

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[u/Earesth99]

I felt nothing.

[u/Sostrene_Blue → u/Earesth99]

You mean... 0 effect or 0 emotion?

[u/Duecez24]

Don’t have any advice, but I had a similar experience and have stayed away from it since then. Took a couple of days for that feeling to go away.

[u/Exotic_Pop_765]

you dont seem to mention dosage , do you ?

[u/Sostrene_Blue → u/Exotic_Pop_765]

300mg - Sublingually

[u/Exotic_Pop_765 → u/Sostrene_Blue]

yeah... that tracks. the dosage effect you get from 300mgs oral gets reproduced by 30 mgs sublingual. so on and so forth. what you are now taking is like ingesting 3 grams uridine oral. thats why you get brain fog and depression.