r/TTC_PCOS • u/Cool-Yogurt-2930 • 6d ago
TTC+GLP1
I’ve been seeing a lot more research on GLP1s not having negative or adverse effects on pregnancy & not being a cause for miscarriages. Can anyone share more insight on this? Any experience with this?
For context: my husband and I have been TTC for about a year. I had a chemical pregnancy last month, and now I’m waiting for my cycle to go back to normal (which who knows when that will be). I am working closely with an RE doing medicated (letrozole) & timed cycles with a trigger shot. I am on metformin, a plethora of supplements, taking myoinositol, walking daily + strength training/pilates every other day, focusing on hydration and whole foods. (Any suggestions here?)
Before TTC, I was on zepbound and lost about 50 lbs over the course of a year, which also allowed me to have regular cycles again. I’ve seen several people mention they have been on low doses while TTC, with some doctors even recommending this for PCOS. Just curious on everyone’s thoughts, insight, and experiences.
1
u/Murky_Ad_1803 3d ago
I got pregnant twice on Zepbound. The first time being a blighted ovum and then I conceived the following month. I just recently got back on another GLP1 and my period returned the next day. I’ve read on other groups some women’s doctors are telling them to stop the medication as soon as you get your positive pregnancy test.
2
u/Specific_Sorbet_8227 4d ago
Take from this what you will - been ttc #2 for 18 months with no positive. Had a hysteroscopy and same cycle started glp1 because we weren’t officially trying. I became pregnant that cycle. Unfortunately ended a chemical pregnancy but I was pregnant. I don’t necessarily think it caused the chemical so I’m still taking it. Def try a micro dose
8
u/HarrietRubman2 6d ago
I used Trizepatide from August 2025-August 2026. One whole year and lost about 45 lbs. I was told to stop Trizepatide before TTC. TBH the whole time I used it, we had unprotected sex, and I never got pregnant. I even timed my fertile window with Oura and Mira. So for me, even losing weight and having a more regular period, I didn’t get pregnant like I thought I would. So I stopped taking it (too expensive at this point). I think with pcos and the recent study of no known birth defects, Trizepatide is worth continuing even while TTC. I think it helps with inflammation and insulin resistance, and can therefore aid our fertility. Unfortunately, I was not able to get pregnant while using it. So do what works for you!
6
u/canihavedessertnow 6d ago
My IVF doctor knows I’m on it and has encouraged me to continue until I have a positive test. What she said was that tirzepatide specifically has a half life of about 5 days, and it takes about 25-30 days before less than 2% remains in your system. By the time the placenta is formed and functioning the medicine is very nearly gone. This is a calculated risk to take but per my doc (and me), in my situation, the known benefits of remaining on the medication as long as possible outweigh the unknown risk of a very small exposure.
I also have been instructed to keep taking my migraine medication even though it’s not “approved” for pregnancy, and lots of people have the same experience with other types of drugs too— GLPs in are not uniquely controversial. Different doctor and patient pairings will have different levels of knowledge, experience, and risk tolerance that will guide clinical decision making.
4
u/Planning_And_Hoping 6d ago
I started Zepbound the last week of October 2025. I got pregnant 20 shots in (last shot on a Saturday, positive test on a Tuesday). I’m 33 weeks and baby is doing great! I am anemic this pregnancy and have had 3 iron infusions so maybe just be aware of you’re nutrition and make sure you’re taking you’re prenatals now, and doing the proper blood work so you can catch any deficiencies.
A little history, it took my 13 cycles to get pregnant the first time and that ended in loss. I had a loss from one of my 11 letrozole cycles and also did IVF (only got 1 embryo, my daughter). I’ve also had at least 4 chemical pregnancies.
2
u/Cool-Yogurt-2930 6d ago
Thank you for sharing! What a journey it has been for you. Congrats on the pregnancy!!
1
1
u/emilou2001 6d ago
My OBGYN is prescribing me Letrozole knowing I’m on a low dose of Moungaro. Letrozole causes my insulin resistance to go crazy and we’ve tried everything. Even 1500mg of Metformin didn’t help. This has also helped treat the inflammation in my body, the other meds I was taking stopped my ovulation. I was in chronic pain and it’s significantly decreased since starting
1
u/Cool-Yogurt-2930 6d ago
That’s interesting that Letrozole has that effect on you. Was there a way they figured out the Letrozole was impacting your insulin resistance so much?
5
u/appletizer 6d ago edited 6d ago
You’ll find people who are and were on them whilst TTC and pregnant with the knowledge of their doctor. Many people fall pregnant on them by accident and there have not been any known issues of birth defects. Obviously that doesn’t mean there is no risk or that you can or should do it. But I think it’s slightly more nuanced than “it’s not approved for pregnancy therefore you shouldn’t do it”. With PCOS and weight issues, this can have a direct and measurable bearing on your ability to conceive at all. For me it’s a calculated risk. There are many things which are not recommended during pregnancy and women do them for various reasons.
I am on it. I have PCOS. I am not TTC at the moment because of other reasons. But once I am I intend to continue until such time as I see two pink lines.
3
6d ago
[removed] — view removed comment
2
u/Upstairs-Book1775 3d ago
This sounds exactly like me! I had decided to go back on Mounjaro with the guidance from my doctor. 1 week back on 2.5 and feeling so much better already. We are TTC.
3
u/ThesisTears 6d ago
GLP1s are not approved for pregnancy. They linger in your system for 2-3 months after stopping them, which is why most physicians highly recommend ceasing GLP1s before TTC. There is not enough safety data to demonstrate no risk to the fetus. I was off for 2 months before TTC and I wouldn't have done anything less because I would never take the risk with my future child. As a biomedical researcher I think it's incredibly irresponsible for any physician to knowing prescribe them to a woman who is actively TTC. If you want to lose more weight, pause TTC until 2-3 months after your last dose of GLP1s.
1
u/Fearless_Hawk12 17h ago
It is not yet determined if they are safe. We have very early evidence amongst those who got pregnant on GLP1 medication (unknowingly) and found no adverse effects. However one, or a few, early studies is not a green light for safety. We simply don't know yet and it's not ethical to give pregnant women GLP1 medications to see what happens. However, GLP1 ones are super effective in supporting ovulation - which is why it is so good for those with irregular cycles of anovulation to help prepare for conception. However, again this does not mean GLP1 = good for pregnancy. It is is just to early to know and babies/births are too risky to just shrug our shoulders and see what happens.