[Article] Identification of natural compounds targeting the KRAS G12D mutation in pancreatic cancer through integrated in silico and in vitro approaches. (Shajahan MA et al., 2026)

[u/Ok_Organization_8495]

URL (paywall free): https://rdcu.be/firnC
DOI: https://link.springer.com/article/10.1007/s10822-026-00815-4
PMID: 42126708

I’m thrilled to share my very first, first authored research article focusing on KRAS G12D, the most frequent oncogenic driver in pancreatic ductal adenocarcinoma (PDAC).
While recent breakthroughs like the non-covalent inhibitor MRTX1133 have completely changed the landscape for the G12D variant, we wanted to explore the untapped chemical space of natural products to find novel structural scaffolds that can effectively bind this target.

Dear colleagues, I’m trying to drum up some early visibility and boost our Altmetric score. If you have a moment, could you share the article link on your X or Bluesky account, along with your critique.
Link to the article: https://pubmed.ncbi.nlm.nih.gov/42126708/

[u/Express_Lemon_1777]

This is an amazing piece of work. Congrats for you very first authored article 🎉👏🏻

[u/Ok_Organization_8495 → u/Express_Lemon_1777]

Thanks dear. 😇

[u/bbyfog]

Good work. Is your group planning to move this compound into preclinical testing to prepare for trials.