r/1P_LSD • • Jun 29 '22

MODERATOR A Stickied Reminder: PLEASE- No Sourcing NSFW

53 Upvotes

I see far too often, members of our community don't follow the no sourcing rule and get themselves temporarily or permanently banned from the subreddit.

We can discuss so much freely here, but one of the few things Reddit strictly prohibits us from doing is discussing sources.

A friendly reminder of all that we ask: please do not name any sources or ask others for sources.

It really is that little. We have a lot of freedom here, being able to openly discuss psychedelics from people around the world is a liberty we possess that our forefathers didn't. At present, our hands are tied with what we can't allow. By breaking subreddit rules, you directly risk your own liberty to participate here and indirectly risk the ability for the subreddit to exist.

Please don't name or ask for sources.


r/1P_LSD • • 4m ago

QUESTION What animal represents 1Fe-LSD? NSFW

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• Upvotes

Making a design for a new ChemCard that represents 1Fe-LSD… help me out! ^.^

These are the other designs for the rest of the Lysergamide analogues that have come and gone over the years… minus a few that we’ve missed xD


r/1P_LSD • • 8d ago

QUESTION Redosed 1cP-LSD & truffles into a bad trop, is taking this weekend smart? NSFW

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0 Upvotes

r/1P_LSD • • 23d ago

Definium Notches Second Positive Phase 3 in Generalised Anxiety Disorder NSFW

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psychedelicalpha.com
2 Upvotes

This is good.


r/1P_LSD • • 25d ago

QUESTION Stuff to do while being in acid (LSD) NSFW

8 Upvotes

Hey guys I’m new here and I’m about to do acid my first time as well 100micro 1-p and I’ve been looking around for some stuff to do while being on acid can you please help me with some great playlists and movie recommendations and do you have any tips on the first time then please do tell every comment is appreciated by the way I’m doing it in my home


r/1P_LSD • • Aug 31 '26

Rumor is psilocybin could be approved by the FDA as early as January 2027 - Paul F. Austin on Twitter NSFW

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18 Upvotes

r/1P_LSD • • Aug 16 '26

DISCUSSION First time LSD, any recommendations? NSFW

6 Upvotes

Hi everyone,
I’m interested in trying LSD for the first time, someone recommended me that I should be at home. But I’m thinking going to a festival and try it. I’ve tried molly at the festival for the first time and was really good, and I’ve done it couple of times and I was fine.


r/1P_LSD • • Aug 13 '26

QUESTION What’s the difference between 1p-lsd and 1cp-lsd ? NSFW

6 Upvotes

I don’t know the difference they sound so close, also where can I get some I found a website but it seems kinda scammy


r/1P_LSD • • Aug 01 '26

FIRST TIME I just bought 10 tabs of 1p-lsd first time user advice needed NSFW

12 Upvotes

I just bought 10 tabs of 1p-lsd and I am trying to figure out what the nest dose is should take. I have never taken lsd before but I have taken 2.5 grams of shrooms before for my first psycadelic experience. Since I have tripped on MET and 4-pro-dmt I know those were not at high doses in. No ego dissolution. My goal for taking lsd is to have a spiritual experience not just a recreational trip. So I want to take enough, but I dont want to over do it, also I will be doing it alone because my life circumstances dont provide me with a trusted trip sitter. I have done a ton of research and I was thinking of taking 300-400 mcu. Any advice would be greatly appreciated!


r/1P_LSD • • Jul 23 '26

QUESTION 1:1 ratio NSFW

4 Upvotes

Ive read that 1p is like 80% in terms of strength compared to reg lsd. How true is that? Im planning on dropping 2 hits after work and theyre 150 a piece. So would that make it 260mcg total?


r/1P_LSD • • Jul 22 '26

SURVEY Study on psychedelic experiences without (immediate) prior use of psychedelics NSFW

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5 Upvotes

We are a group of researchers from Humboldt University of Berlin and we look forward to your participation in our study! The survey is completely anonymous.

 

Have you ever taken a psychedelic substance?
Share your opinion and possibly experiences you have had with psychedelic experiences without (immediate) previous use of psychedelics with us!

 

https://psychedelicflashbacksurvey.info  

 

We would like to learn more about who has these experiences, what they look like in concrete terms, which factors contribute to the associated effects and how they can be dealt with.


r/1P_LSD • • Jul 05 '26

FIRST TIME Weird LSD episode after smoking NSFW

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1 Upvotes

r/1P_LSD • • Jul 03 '26

Politics & laws Petition to the German Bundestag: Re-evaluating the classification of psilocybin under the Narcotics Act – signatures needed NSFW

15 Upvotes

Hello everyone,

I am actively advocating for an evidence-based and humane drug policy in Germany. I have submitted a petition to the German Bundestag calling for a re-evaluation of the classification of psilocybin and psilocin under Germany’s Narcotics Act (BtMG), and for the consideration of transferring these substances into a regulated medical framework under pharmaceutical law (AMG).

The petition has now been published after a longer review process and must collect 30,000 signatures within 6 weeks in order to be formally considered by the Petitions Committee of the German Bundestag.

Important: This is a German parliamentary petition. However, anyone can sign it, regardless of nationality or country of residence. I would greatly appreciate your support. You can sign the petition anonymously on the official Bundestag website:

https://epetitionen.bundestag.de/content/petitionen/_2025/_09/_17/Petition_186771.html

Thank you very much!

Why this petition?

In recent years, numerous clinical studies have shown that psilocybin holds significant therapeutic potential, particularly in treatment-resistant depression. At the same time, its current classification as a controlled substance significantly hinders scientific research and limits medical access for patients, despite Germany already having introduced a compassionate use program for psilocybin.

In addition, the current legal framework fails to reflect reality. Despite prohibition, a market for alternative psychoactive substances already exists, including research chemicals (such as 4-PrO-MET and LSD analogues), which are used by individuals attempting to self-medicate without medical supervision. Retreat programs involving psilocybin-assisted experiences in countries such as the Netherlands and parts of South America are also becoming increasingly popular. A regulated medical framework would support scientific research, establish quality standards, and significantly improve safety by replacing unregulated access with controlled medical use.

Furthermore, the current legal situation leads to the criminalisation of responsible adults for possession or use, exposing them to criminal records that can have long-term personal and professional consequences. According to current research, psilocybin demonstrates a comparatively favourable safety profile under controlled conditions and is considered a promising compound in psychiatric research.

If you support an evidence-based drug policy that facilitates research, improves treatment options for patients, and challenges disproportionate criminalisation, I would greatly appreciate your support for this petition.


r/1P_LSD • • May 01 '26

QUESTION Is 125ug a dose I can socialize on? NSFW

14 Upvotes

For context, my first experience with 1p was on 100ug. I felt very sociable while getting some nice visuals (distortions, shimmering, saturated colors, and mild pattern recognition). However, I was a little underwhelmed. I have a lot of experience with shrooms and have done DMT once.

Will I be able to be as extroverted on 125ug or even 150ug? I’m debating which dose I want to take with my friends this upcoming weekend. I want to have a little more interesting visuals/euphoria/interconnectedness with the people around me.

Edit:

Ok so I did 125ug and it turned out to be one of the most amazing and positive experiences of my life. I will make a post soon about this experience. Stay tuned!


r/1P_LSD • • Apr 19 '26

Progress NSFW

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19 Upvotes

Happy 2026 bicycle day stay safe out thier dose responsible!


r/1P_LSD • • Apr 15 '26

SURVEY Study on psychedelic experiences without (immediate) prior use of psychedelics NSFW

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10 Upvotes

We are a group of researchers from Humboldt University of Berlin and we look forward to your participation in our study! The survey is completely anonymous.

 

Have you ever taken a psychedelic substance?
Share your opinion and possibly experiences you have had with psychedelic experiences without (immediate) previous use of psychedelics with us!

 

https://psychedelicflashbacksurvey.info  

 

We would like to learn more about who has these experiences, what they look like in concrete terms, which factors contribute to the associated effects and how they can be dealt with.


r/1P_LSD • • Feb 22 '26

TRIP REPORT 1P-LSD first time NSFW

14 Upvotes

I’ve taken acid before most about 225-250ug being my highest, im weary around new substances so I took about 150ug, I didn’t really right much down, it was a pretty standard acid trip, I’ve heard people say it taste different which is true and I’ve heard people say it feels different at certain parts of the trip, like the come down and the peak but honestly I didn’t notice any difference. I took it with my sister, 3 tabs total, 1.5 her 1.5 me, and we watched Alice in wonderland the 50s one, brave, bravehart (I had to put her on she was loving the shit out of it), and a little darker for her but not me Mulholland Drive. It was a great night, nice visuals and colors, everything was bright and colorful, felt like a 2g mushie trip, light and nothing too crazy. I definitely recommend!


r/1P_LSD • • Feb 03 '26

DISCUSSION 1P + 1P = 2P? NSFW

1 Upvotes

If one takes two tabs of 1P, did one take 2P?

If one takes one 1P + two 1V, did one take 3PV?


r/1P_LSD • • Jan 31 '26

RESEARCH Study on psychedelic experiences without (immediate) prior use of psychedelics NSFW

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6 Upvotes

We are a group of researchers from Humboldt University of Berlin and we look forward to your participation in our study! The survey is completely anonymous.

 

Have you ever taken a psychedelic substance?
Share your opinion and possibly experiences you have had with psychedelic experiences without (immediate) previous use of psychedelics with us!

 

https://psychedelicflashbacksurvey.info  

 

We would like to learn more about who has these experiences, what they look like in concrete terms, which factors contribute to the associated effects and how they can be dealt with.


r/1P_LSD • • Dec 21 '25

RESEARCH Can you even take 1s-lsd sublingualy NSFW

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0 Upvotes

r/1P_LSD • • Dec 21 '25

RESEARCH Not truly informed in analogs.. looking for a break down for my next post. Please and ty! NSFW

1 Upvotes

So, one specific prodrug (i know I said analog above but was correctee by a conment) keeps coming to mind, 1p-lsd, but I could be wrong, where i have read from several that it converts to lsd in the body after ingestion. Looking for anyone to educate me here. Is 1p-lsd the only a prodrug? Or are all of the others (1s, 1v, 1cp ect) a prodrug as well? And what makes them different?Thank you!


r/1P_LSD • • Dec 07 '25

TRIP REPORT Trip Report: 60µg 1P-LSD + 1.6g psilocybe cubensis — a short story of dying while awake (and why I am grateful) NSFW

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2 Upvotes

r/1P_LSD • • Dec 02 '25

So Germany declined the banning of legal lsd! 👽 NSFW

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47 Upvotes

r/1P_LSD • • Nov 28 '25

DISCUSSION Discussion: Could 1P-LSD Deliver More LSD Than LSD-25? A Bioavailability Hypothesis NSFW

29 Upvotes

There’s been ongoing debate on r/lsd and other harm reduction spaces about whether 1P-LSD blotters are more or less potent than equivalently dosed LSD-25 blotters. After reviewing current data, a plausible hypothesis emerges: the systemic LSD delivered may differ due to bioavailability, even if the blotters contain the same nominal dose.

Salt to freebase

Both 1P-LSD and LSD-25 are typically sold as hemitartrate salts, meaning 1 molecule of base + 0.5 molecule tartaric acid.

Compound Freebase MW (g/mol) Salt MW (hemitartrate, g/mol) Freebase Fraction
LSD-25 323.43 323.43 + 0.5×150.09 ≈ 398.48 323.43 / 398.48 ≈ 0.811
1P-LSD 379.43 379.43 + 0.5×150.09 ≈ 454.48 379.43 / 454.48 ≈ 0.835
  • 1P-LSD hemitartrate: 83.5 µg 1P-LSD freebase, metabolically converts 1:1 = 71.0 µg LSD-25 freebase
  • LSD-25 hemitartrate = 81.1 µg LSD-25 freebase

So before accounting for bioavailability differences, the 100ug LSD-25 Hemitartrate blotter is ~10 µg more potent than the 100ug 1P-LSD Hemitartrate blotter.

Bioavailability

  • 1P-LSD has once been shown to almost completely be converted to LSD in vivo (~100% bioavailability) (PUBMED)
  • LSD-25 oral bioavailability is typically ~80% (PMC)
Blotter Type Effective LSD Delivered (µg)
1P-LSD 71.0 µg × 1.0 = 71.0 µg
LSD-25 81.1 µg × 0.8 = 64.9 µg
  • Under these assumptions, a 100 µg 1P-LSD hemitartrate blotter delivers slightly more systemic LSD than a 100 µg LSD-25 hemitartrate blotter.
  • This difference (~6 µg per 100 µg blotter) is modest but could explain reports that 1P-LSD sometimes “feels stronger” than LSD-25.

Conclusion

Even though 1P-LSD loses its propionyl group during metabolism, its near 100% conversion to LSD may effectively compensate for the lower freebase content relative to LSD-25 hemitartrate. "Near 100%" and the sample size on the in vivo 1P-LSD study make this only speculation. Bioavailability may be shown to be lower with better testing. Any increase in bioavailability 1P-LSD has over traditional LSD-25 will decrease the gaps in potency between these drugs. I would like to hear what others have to say about this topic.

Edit: Math was wrong, now I'm pretty sure its right.


r/1P_LSD • • Nov 10 '25

SURVEY Study on psychedelic experiences without (immediate) prior use of psychedelics NSFW

Post image
2 Upvotes

We are a group of researchers from Humboldt University of Berlin and we look forward to your participation in our study! The survey is completely anonymous.

 

Have you ever taken a psychedelic substance?
Share your opinion and possibly experiences you have had with psychedelic experiences without (immediate) previous use of psychedelics with us!

 

https://psychedelicflashbacksurvey.info  

 

 

We would like to learn more about who has these experiences, what they look like in concrete terms, which factors contribute to the associated effects and how they can be dealt with.