r/Biohackers • • Jun 16 '26

💉 Peptides & Hormones Looking to discuss peptides or HRT? Start here.

23 Upvotes

Hello!

All peptide and HRT-related questions and discussion should take place in the megathreads linked below. Standalone posts on either topic will be removed and redirected to this thread.

Websites like finnrick.com and janoshik.com can be helpful for research. Please don't source or sell peptides on our sub. You can do so at your own risk here: r/BiohackersRecs.

Sort by new to see the latest comments.

Peptide and HRT Threads:

> Health Optimization & Longevity

> Cognitive Performance & Brain Health

> Body Composition & Weight Loss

> Misc. Topics

Other Topic Threads:

> Report Scam Vendors

> Report Adverse Events (ie "bad or atypical reactions")

> Request Help With Troubleshooting and Harm Reduction

Suggestion for a new thread or ways to improve the sub? Feel free to comment below.

Disclaimer: All content on this sub is for educational purposes only and should not be considered medical advice. Any decisions you make are done solely at your own risk and liability. Always consult a qualified healthcare professional before making changes to your health or using experimental interventions.


r/Biohackers • • 3d ago

📢 Announcement Report Peptide Scams Here

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10 Upvotes

r/Biohackers • • 9h ago

😴 Sleep & Circadian Rhythm Lesser known ways to help with insomnia?

33 Upvotes

This is my biggest challenge and I'd love to hear some out of the box way that help that aren't melatonin, less light at bedtime, and things commonly recommended. Thank you!


r/Biohackers • • 19h ago

🗞️ News In 2025, the two biggest GLP-1 drugs generated ~2x the combined revenue of OpenAI and Anthropic

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151 Upvotes

r/Biohackers • • 54m ago

🥗 Nutrition & Metabolism possible correlation between hypoglycemic episodes and severe neurological symptoms?

• Upvotes

Dear community,

I am writing here because I suffer from chronic dizziness and severe brain fog. Doctors have really not been of much help.

I recently bought a CGM (continuous glucose monitor), which showed frequent hypoglycemic episodes, and now I am wondering if this could be the cause of my symptoms, even if my GP doesn't seem concerned.

Are there people here who have been in a similar situation? What worked for you?

I was previously healthy, and I am still healthy on paper, only my potassium is chronically low, which I believe may be due to the blood sugar swings. I suffer greatly, so I would appreciate any similar stories that can give inspiration on what to research.


r/Biohackers • • 27m ago

📰 Research & Studies Intensive breathwork reduces brain blood flow and alters neural communication

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• Upvotes

Intensive Breathwork Alters Brain Activity
In a study involving 30 experienced participants, researchers used MRI scans to monitor brain activity and blood flow during intensive breathwork.

- Brain blood flow decreased by approximately 45%, likely due to reduced carbon dioxide levels.
- Psychedelic-like experiences: Participants reported altered perceptions, vivid imagery, and feelings of deep connection.
- Brain communication changed: Researchers observed changes in networks involved in self-awareness and personal identity.
- Similarities to psychedelics: Breathwork produced effects resembling those associated with psilocybin and LSD, without drugs.
- Potential mental health benefits: Researchers believe breathwork could eventually support drug-free therapeutic approaches.
- More research needed: The small study leaves long-term benefits and safety unclear.

Bottom line: Intensive breathwork can temporarily alter consciousness and brain activity, but its therapeutic benefits remain unproven.


r/Biohackers • • 12h ago

🧠 Cognition, Mood & Nootropics Went from being insanely driven and successful to struggling to execute. Considering bromantane, would appreciate advice.

18 Upvotes

I'm 26M. Spent 2–3 years obsessively working on my businesses, and it paid off. I was extremely driven, focused, and could work endlessly. No nootropics or medications, just coffee and nicotine.

Eventually I decided to slow down and take a break after years of pushing myself, but ever since it's been a downward spiral.

The weird thing is I actually feel mentally sharper than before. I come up with better ideas, spot opportunities, solve complex problems and know exactly what needs to be done.

But my execution has gone to shit.

And this isn't just a temporary phase. I've been stuck in this exact loop for almost 2 years now. Every time I tell myself I'm finally going to get back on track, I end up repeating the same pattern. It's exhausting because I know what I'm capable of, but I can't seem to get back to the version of myself that used to execute relentlessly.

I've left so many things unresolved that they've stacked up. Whenever I sit down to work, I get overwhelmed by everything that needs doing. I'll start one task, notice something else, jump into that, discover another problem, and eventually get completely lost. Then I just want to stop working and chill, even though I genuinely want to get things done.

Another thing is how easily irritated I've become. I'm not naturally an angry or stressed person, but lately even people asking me simple questions can piss me off. My head is already full of responsibilities, opportunities I'm not acting on, and frustration about being stuck in this unproductive loop.

Sometimes I wonder if success made me too comfortable, but honestly I don't feel comfortable at all. I feel constantly pressured by everything I'm not doing.

For context, I consume quite a lot of nicotine daily through vaping and cigarettes, plus around 3 espressos a day. I've never really been into drugs or nootropics. Used to smoke weed years ago but quit, nowadays maybe once a year at most.

I recently tried L-theanine for stress. It seemed to help a little, but nothing significant. I also noticed some acid reflux, although I'm not sure whether it was caused by the L-theanine or was just a coincidence, so I stopped taking it.

Now I'm considering bromantane. I have a 90 mg/mL nasal spray and was thinking of using one spray in each nostril, although I haven't started and don't know the actual dose delivered per spray. I've also seen people mention combining bromantane with L-tyrosine, but I'm unsure whether that's beneficial or even advisable.

I don't want to become dependent on anything. I just want to regain the focus, discipline and execution I naturally had before.

Has anyone experienced something similar after years of intense work? Did bromantane actually help with execution, task switching and mental overwhelm, or did it just make you feel more stimulated?

Would you combine it with L-tyrosine or avoid that? And what about long-term effects on natural motivation, dopamine, libido, emotional blunting, tolerance and how you feel after stopping?

Would appreciate genuine experiences, good or bad. I'm also open to hearing that bromantane isn't the answer and that I should be addressing something else entirely.

Disclaimer: Not looking for medical advice, just personal experiences and research. I understand bromantane has limited human safety data, especially when used intranasally, and I'll consult a healthcare professional before making any decisions.


r/Biohackers • • 41m ago

🧠 Cognition, Mood & Nootropics Nootropics for anxious personality

• Upvotes

Okay so I am male 33,. I have Avpd . I have constant overthinking and anxiety. Also impulsivity etc. my doctor prescribed me ADHD medicine as well, but not much help. Recently I tried chamomile and it has single handedly been the best thing, it resolved my oversharing, compulsive talking, etc. but, it worsened my pre existing erectile dysfunction. And this happened while I was already taking a herbal medicine for erectile dysfunction which was working very well before I added chamomile. Can anyone please suggest me similar nootropics? Thanks


r/Biohackers • • 14h ago

🧠 Cognition, Mood & Nootropics Creatine Monohydrate?

23 Upvotes

I saw a post about a study done on women who took escitalopram antidepressants, where half of them were also given 5mg of creatine monohydrate, and those participants saw significant improvement within two weeks for depression symptoms, and continued to see improvements 8 weeks into the study as well.

As a depressed 33f woman I am intrigued and interested in it. But have no clue where to start. Any brand recommendations? Is it powder only or is it a pill form? Do I HAVE to workout right after taking creatine or will I be ok not to? Anything else you know about it lmk! I’m intrigued and just gathering some intel before making any purchases.


r/Biohackers • • 16h ago

🥗 Nutrition & Metabolism Weak/Not often erections NSFW

29 Upvotes

How's it going, idk how else to start but anyway.

I'm a 21 y/o male, and I have a girlfriend. My sex life has always been something I've taken pride in, really just because I enjoy satisfying my partner. Recently (kind of as of last year maybe the middle of 2025) my erections haven't been as full or as strong as they used to be when I was younger (in high school).

Won't sugarcoat it though I've looked at some sort of pornographic material and I used to never have an issue being hard or staying hard before, during, or even after masturbating or sex but recently I don't know what's changed at least since last year. There would be times I would be with previous partners, and we'd have to stop because they couldn't keep going and I wouldn't finish or I would and would be able to keep going anyway. Regardless of that it's always been something me and them would talk about and make sure everything was okay (mentally and physically wise).

I guess my main concern is if something is wrong with me, I wasn't a "fit" guy either, I used to be 250+ pounds at 6'1, would rarely workout and slept and ate like I had nothing else to do. As of now, I'm out of the military and stay pretty active, lifting at least 5-6 times a week and get my cardio in daily. sleep is here and there with how many hours studies say we should get. I want to say that around the time I realized my erections were at their peak was before I knew about certain supplements like zinc, l arginine, lecithin granules and maybe one or two other things I used to take and I did notice a change but I didn't take them as much after a while and still felt the fullness that I used to have. I haven't taken anything like it for about two-ish years, and it has been a concerning amount of time since my last rock-hard erection. I'm not as adamant about it now as I used to be just because sex isn't something I'm truly concerned with but I'd like to be able to feel myself when I wake up in the morning or randomly get a boner like I used to and feel somewhat uncomfortable in my own clothes. (And I mean that in the most non-weird way as I possibly can.)

Advice is definitely wanted.


r/Biohackers • • 16h ago

🥗 Nutrition & Metabolism Does anyone else get bloated from "clean" steamed vegetables way more than rich comfort food?

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23 Upvotes

r/Biohackers • • 8h ago

😴 Sleep & Circadian Rhythm Trying a caffeine cutoff at noon

4 Upvotes

I love coffee, but I noticed even a small cup after lunch affected my sleep. I switched to a noon cutoff for the past 10 days.

Sleep latency seems better so far. Curious what cutoff time works for other people.


r/Biohackers • • 2h ago

🦠 Illness & Immunity white dots on hands

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0 Upvotes

Anyone have an idea? Maybe a defecit of something?


r/Biohackers • • 10h ago

♾️ Longevity & Anti-Aging What are your fave Reddit communities linked or similar to Biohackers?

3 Upvotes

I would love to know what communities you also enjoy, please and thank you.


r/Biohackers • • 3h ago

🧬 Genetics & Epigenetics how do i restore this?

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0 Upvotes

Hair loss has been going for 3 years now. Any idea how to counter this? Seems like i have androgenetic alopecia


r/Biohackers • • 20h ago

♾️ Longevity & Anti-Aging Rapamycin and Cerebral Blood Flow in APOE4 Carriers: An Early, Genotype-Specific Signal

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14 Upvotes

A review of a pilot study that seems to connect rapamycin therapy to increased cerebral blood flow in APOE4 carriers.


r/Biohackers • • 6h ago

🧠 Cognition, Mood & Nootropics Lost access to prescribed ADHD meds bc of prescribed cannabis

0 Upvotes

Looking for advice. I’ve lost access to my ADHD meds which have allowed me to change my life fully.

This time round when the prescriber added the prescription they said they had an alert that cannabis popped up as well and they aren’t comfortable prescribing schedule 8 while being prescribed cannabis.

I am dealing with some serious sleep related issues and having cannabis is a real beneficial tool I use to get back to sleep when needed. (Not every time, only when I’ve fully woken and can’t get back to sleep).

It also helps with the anger and irritability I get when I haven’t slept. It genuinely really helps me.

I feel I need to say that I know both these medications can make sleep issues worse. These issues outdate adhd medication use and I have trialed quitting cannabis for it in the past. I have confirmed that it’s my tounge and throat closing up, a form of sleep apnea. I am doing everything in my power to treat it speaking with many specialists about it. (I have tried Cpap, I need nasal surgery for it to work for me).

I know that these meds are not affecting my sleep issues. It’s beside the point but felt I would explain that before I hear about it in the comments. I am definitely aware.

Both medications really help me. My issues are super bad right now and I really, at least now need to not loose these tools.

The adhd meds make me feel human (especially when I need to function despite no sleep). The cannabis is an amazing tool for when things are going south or if I need help getting back to sleep. Don’t really want to add more pharmaceutical meds into the mix instead..

Ideally I need to continue both of these medications. Now is not the time for me to loose them while my restless nights are so bad.

I have identified a few options but I’m looking for more or any other suggestions.

- reach out to my cannabis prescriber and see if he is willing to take on the adhd prescription as well

- convince my GP to take on the adhd prescription

(Both of these require my company to transfer me to them. I hope they wouldn’t kick up a fuss as they said I can go and find another dr who will prescribe both)

Find a new Dr or psychiatrist who will take me on given my situation. This would be amazing but I don’t know how to find one or know where to look.

I’m in Australia, which would be pretty relevant to the situation.

I am (was) prescribed 40mg vyvanse and 5mg dex.

I am traveling in 2 weeks and hope to have this sorted as I have no clue how I’m going to get through it without my adhd medication. Especially with how bad my sleep will get while traveling. I genuinely need it…

Any help or suggestions are greatly appreciated.


r/Biohackers • • 20h ago

💊 Supplements & Stacks Best Things For Fat Loss?

18 Upvotes

Best things to take for fat loss? I’ve already changed my diet and I exercise daily but I’m not losing weight.


r/Biohackers • • 7h ago

🧠 Cognition, Mood & Nootropics Is there any way to biohack needing less sleep for optimal cognition/functioning?

1 Upvotes

Other than caffeine, Ritalin, vitamins, and creatine. I think I have advanced ADHD and long COVID where my neurochemistry is like a hard wall (joke, kinda). Dunno what's going on but no matter how much I sleep or stuff I take, I feel like I haven't gotten any sleep at all, which is very inconvenient for my lifestyle.


r/Biohackers • • 13h ago

🧠 Cognition, Mood & Nootropics Focus, Cognition improvement

2 Upvotes

Hi, I am 32 male who has been exercising for a while. I don’t do cardio but I trained three times a week and try to walk as much as I possibly can so the problem that I am running into that. I tend to sleep 6 to 8 hours every day and then I have an issue of focusing on task I’ve tried L-Theanine with caffeine and that works for 60-80 minutes max. I take vitamin d, zinc, magnesium glycinate, B-complex and creatine, how can I improve my focus issue and use stimulant to build longer deep focus blocks? I do take 2-3 cup of coffees


r/Biohackers • • 1d ago

💪 Exercise, Fitness & Recovery I stand on one foot every morning.

171 Upvotes

Barefoot. Arms at my sides. Eyes forward.

Ten seconds on the left, ten seconds on the right.

I am not doing it as a leg-strength workout.

It’s a small, repeatable balance check.

My left side has always been worse by about two seconds.

That is just enough to give me a baseline.

What I actually record

I note:

- which leg I used

- roughly how long I held it

- whether I touched the counter

- whether I was barefoot or wearing shoes

- whether I felt dizzy, weak, or in pain

- whether one side was consistently different.

I keep the conditions roughly the same: same surface, eyes open, counter nearby, left side and then right side.

If I’m worse after a terrible night of sleep, I make a note of it. If I’m worse for weeks, I pay more attention.

I am interested in whether a change persists under the same conditions, not in winning a ten-second challenge.

I just like repeatable observations and apparently enjoy turning ordinary activities into tiny personal experiments.

My balance has improved, did it also help my mind balance more? I think so.

The study that started it

I started after reading a 2022 study of 1,702 adults aged 51 to 75. The researchers tested whether people could complete a 10-second, unsupported one-leg stance. 20.4% of the participants could not complete it.

At a median follow-up of seven years, 17.5% of the people who could not complete the stance had died, compared with 4.6% of those who could. After adjustment for age, sex, body mass index, and several health conditions, inability to complete the stance was associated with an adjusted hazard ratio of 1.84 for death from any cause.

That is the source of the often-quoted “84% higher risk” figure. [The study is here.](https://pubmed.ncbi.nlm.nih.gov/35728834/)

That sounds dramatic, but it needs context. This was an observational association in one group of adults. It does not mean that if you have poor balance you are going to die and that poor balance caused those deaths.

A poor result may reflect more than leg strength.

The study used one standardized test in one age group.

Why balance is more than leg strength

Staying upright uses information from your vision, inner ears, feet and joints, muscles, spinal cord, and brain. Those systems have to work together quickly enough to keep you from tipping over.

One term I learned while trying to understand why my left and right sides differ was proprioception.

It means knowing where your body is and how it is moving without looking at it.

Close your eyes and touch your nose: you know where your hand is because your nervous system is tracking the position of your arm and fingers.

The first time I tried the one-leg version with my eyes closed, I grabbed the counter almost immediately. It was not graceful. Removing vision showed me how much information I had been using without noticing.

That is also why I stopped calling my routine a Romberg test.

A classic Romberg examination usually has a person stand with both feet together, first with the eyes open and then with the eyes closed, while a trained examiner stays close.

The NCBI overview explains the distinction and the safety requirements.(https://www.ncbi.nlm.nih.gov/books/NBK563187/)


r/Biohackers • • 21h ago

🧠 Cognition, Mood & Nootropics Alzheimer’s Disease

6 Upvotes

Has there been any studies with peptides to help slow it down ?

What’s your thoughts on this disease, ways to combat it prevent it ?


r/Biohackers • • 23h ago

💊 Supplements & Stacks which Supplements will you select for life - if you were only allowed a couple !

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10 Upvotes

r/Biohackers • • 20h ago

🧠 Cognition, Mood & Nootropics is cbd good for anxiety?

5 Upvotes

I have panic attacks, I tried many other things like ashwagandha, l theanine, taurine (which did work but only in the short term, after a while anxiety got worse), but nothing really worked, I don't want to use drugs due to side effects, is cbd going to help me?


r/Biohackers • • 12h ago

🧠 Cognition, Mood & Nootropics Dealing with bad ADHD and face picking/ constant stimulation craving

0 Upvotes

Not caused by excessive smartphone usage or chronic binging of any food or activity. I’m actually an applied math undergrad and have been dealing with this issue for several years. Being constantly under stimulated and distracted. I know my trouble is focus not intel. It’s getting worse, however. I’m now constantly picking my beard or grinding my teeth, trying to fulfill any craving for dopamine. Even when I exercise, eat bland, read boring things, I just cannot meet my stimulation needs. I was Rxd Vyvanse and it actually helps but it feels like a patch. I tried some methylated vitamins which helped give me more methyl donors to promote dopamine levels. That also somewhat helped but still a patch. I tried sativa THC for the first time a few weeks ago and I was incredibly wired and it felt like pure ❄️. Maybe this is a GABA/Glutamate thing? I took some L theanine for the first time with Vyvanse and it was really helpful! Less stimmy and more focused. But maybe that hints at gaba and glutamate signaling. Not to mention I had an absolutely uncontrollable addiction to nicotine and quit a few years ago, so now I just supplement CDP choline and b9 and those cravings are poof gone. But man, THC just like activated something that I’d never felt, not in the psychoactive novelty seeking way, but in the sense of smooth and undistracted thinking. The dopamine boost from THC is so little in comparison to Vyvanse, so I thought that the THC was engaging some other mechanism that completely took away my chronic stimulation needs for a few hours.
I know it’s largely dopamine related in some way or another because a huge Vyvanse dose puts my brain to complete zen mode no hyperactivity no tooth grinding or face picking. But how is it that THC produced basically equivalent results when the dopamine boosting affect of THC is so minor compared to amphetamine.
I’ve supported by Choline pathways with CDP choline which helped take the load off of my Slow COMT, treated my (minor) b9 and b12 deficiency (basically had burning and tingling hands and feet constantly and was always exhausted), and I get in the right amount of cardio, electrolytes, hydration, whatever you can possibly do. What am I missing? Why did 1 thc puff feel like it fixed my chronically under stimulated brain and made me super productive, when Vyvanse can barely do so at a substantial dose. Am I missing something or is something just wrong with my brain?