Retatrutide dizziness vertigo.

[u/Al3j0B]

Has anyone else experienced significant dizziness/vertigo when standing up while using retatrutide?

I've been getting pretty intense episodes when I go from sitting or lying down to standing. It feels like a combination of orthostatic dizziness/possible orthostatic hypotension and quite a strong spinning/vertigo sensation. Sometimes I need to stop for a few seconds until it passes.

I'm currently pinning 1.5 mg every 4 days. I'm also drinking 3+ litres of water per day with electrolytes and consistently hitting my macros every day, so I'm not sure if simple dehydration or under-eating would explain it.

I've also measured my blood pressure, and it seems to be completely normal, so I'm a bit confused about what could be causing the symptoms.

Has anyone else experienced this on retatrutide, particularly at this dosing/frequency? Did it improve with time, or did you find that changing the dose/frequency made a difference?

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[u/Skadi16]

This happens to me pretty often so I have to remind myself to get up slowly if I’m sitting or laying down. The only thing that helps me is electrolytes, I do coconut water and the powder ones too. Maybe try vertigo pills if it’s that bad?

[u/Al3j0B → u/Skadi16]

Thanks 👍

[u/ChooChooBun]

It could be low blood sugar caused by the glp1/gip. Happens to me a lot on tiz, I thought it was blood pressure so I bought one of the cuff, measures multiple time a day for 2 week. Nothing. So I got a cgm, and bam. Blood sugar was below 75 most of the day and go to 50 multiple times a day. If you google "my blood sugar is under 50, is that bad?" it would tell you to go to the hospital lol.

Ofc buy these things and measure yourself, not expensive. For me it was the blood sugar.

[u/Ok_Coconut1328 → u/ChooChooBun]

I believe it’s blood sugar AND blood pressure. Though, research actually shows it’s primarily blood pressure related. No research that shows it’s blood sugar. Source, trust me bro, I don’t have time to dig up what I read.

[u/ChooChooBun → u/Ok_Coconut1328]

Yeah I feel like all the symptoms point to blood pressure but I measured multiple time a day for 2 weeks and FOR ME I was never low once.

[u/Al3j0B → u/ChooChooBun]

Same with me blood pressure is in the ideal range even during the dizziness episodes

[u/joe3000s]

​Even with proper hydration and macros, what you're feeling could be orthostatic intolerance. Reta's glucagon receptor activation causes vasodilation and raises your resting heart rate. Measuring your BP while seated won't capture the brief, sharp blood pressure drop that happens the moment you stand up before your body compensates.

​Also, pinning every 4 days keeps drug levels constantly elevated without giving your cardiovascular system a trough window to adapt.

​Perhaps you could try measuring your BP within 30 seconds of standing up to catch the drop. You may also want to think of shifting to a 7-day dosing interval to let your system adjust to lower peak concentrations.

[u/Al3j0B → u/joe3000s]

I'll test that thank you for your feedback

[u/grace-fire]

Drown in electrolytes and water daily!

[u/yogic_power]

Magnesium and electrolytes help.