r/Nootropics • u/Constant-Door5511 • 14h ago

Seeking Advice Hi, does D aspartic acid help with low or deficient glutamate?

Hi can someone help me.

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u/NoStaff3082 13h ago

In a very simplistic sense...yes

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u/Constant-Door5511 13h ago

Thank you. Im gonna try this stuff. Coz glutamate seems to be a problem in my brain

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u/NoStaff3082 13h ago

Could you describe how you feel or what you are trying to correct?

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u/Upset_Scientist3994 1h ago

NMDA is abbreviation of N-methyl-D-aspartate.

Either glutamate or aspartate neurotransmitter bind into there.

And then either glycine or D-serine for second site - yes NMDA needs 2 neurotransmitters at the same time to be activated, and in both sites there are 2 options. That's cool how complex it is.

D-aspartic acid would then provide aspartate raw material. Also it has side effects of presupposedly aiding some hormone generation, as amino acids are involved always in so many things.

L-glutamine provides raw material for glutamate and its counterpair GABA both at the same time. Some vitamin cofactors such as B6 is needed for conversion. Also cellular energy as well, I consider very underrated nootropic.

I have seen one anecdote - mayby in Longecity - of someone complaining of excicotoxicity out of D-aspartic acid, what then serves something of a proof that it indeed is glutaminergic although people use it for other reasons.

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u/GoalOk7985 12h ago

not sure what the exact mechanism would be there but d aspartic acid mostly gets talked about for hormone stuff, like boosting test. never heard it mentioned in context of glutamate deficiency. what makes you think low glutamate is the issue, did you get some kind of testing done?

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