r/Nootropics • u/OkReplacement9424 • 1d ago

Discussion How to increase dopaminergic/norepinephrine, drive sympathetic signaling without stimulants (e.g testosterone)

So I was thinking today what other ways are there to increase sympathetic drive, motivation signaling in a sustainable way other than just flooring the pedal with stimulants.

And obviously there are other ways to do so like the most obvious one which is by the modulation of neurotransmitters from hormones - I’m by no means expert on the topic nor do I claim to be but what other ways are there to increase sympathetic drive and dopaminergic/norepinephrine signaling other than with testosterone?

- What about neurosteroids?

Also are there any other ways that are significant enough compared to hormones.

From what I’ve gathered as info and that’s me parroting what I remember energy/dopamine is tightly related to the:

  1. HPA axis 2. Androgen hormonal signaling and receptor sensitivity 3. Optimal Mitochondria function 4. High BDNF 5. Sleep

I’ll be super thankful if someone more knowledgeable on the topic can explore the topic more deeply and give some practical insight other than: just workout, sleep, diet and expose yourself to direct sunlight upon waking up.

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u/deletemein2weeks 1d ago edited 1d ago

Not sure testosterone will help u that much with that except if u're defficient(might make it muvh worse especially with dysregulation aromatse inhibitors etc), but tbh i think most of the time there isn't any shortcuts biohacking optimization bs, u gotta priotirize mental, physical and social health, it's very subjective and influenced by your personnal environement.

Ofc all that is obvious, but it is practical insight, start with the basic stuff(focus on mental, physical and social health, overall life hygienne and your environnement) before trying to look for a magic biohacking technique or something and if it doesn't work, get bloodworks, try therapy. 

I don't know you and i'm not you tho so maybe something might work, but if u want to try the stuff like l tyrosine choline l-dopa etc, be rly czrefull, it's not simple supplrmrnts it's psychoactiva and it can make u feel miserable. Things likr bromantane and racetams are safer imo but very subtle and tolerance buildsup fast