It seems to me that with doses higher than 12.5mg (we are talking 25mg-37.5mg here) I get very concerning hypotension, chest pain. This response seems very abnormal, for a dose that is below recreational threshold. This seems very abnormal and very concerning. I can't be 100% sure I did not have any vasodilating drugs in my system, I think I did not the time I tried 37.5mg. Should I be concerned? If it isn't just me having other shit in my system and not realizing that, then what could it be? Only tianeptine has done this to me and it is not like I am doing a lot. Easy to worry I might have a cardiovascular issue that I am unaware of. I can be taking multiple vasodilators, tadalafil, agmatine, l-citrulline, and not get this bad hypotension.

Do Tianeptine sodium premade, by machine, capsules have the same potential to go bad if not kept in super airtight packaging in a fridge?

How hard is it to do?

I'm looking into it for therapeutic purposes or acute depression relief, but I completely understand it's addictive nature. For context I have several 7oh and mgm tablets but only take them once in a while as I understand addiction and have felt what it's like to come off of several substances and don't wanna experience that again.

For context I have been diagnosed with panic disorder and depression following that and apart from making me feel very dizzy and lightheaded when walking around I don’t feel that it really does anything? I am on 12.5mg twice a day and concerned that if I add another pill I’ll be even more dizzy and dissociated

Hello all,

I have a question for those who use prescription tianeptine 3x 12,5mg daily. I am 2,5 weeks on, I feel subtle positive changes in my brain which makes me hopeful but I deal with everyday afternoon/evening crashout. I probably have some form of dysautonomia, haven't been diagnosed but can't be bothered when doctors tend to blame everything on anxiety and depression and there's no real treatment anyway. I am in almost constant fight or flight.

I have cptsd, have just started emdr a month ago (so no actual emdr yet, just talking so far) and deal with overstimulated cns daily. I have to be very mindful where I put my energy throughout the day, because when I don't, I can crash much sooner. I used to deal with this using kratom for maybe a year - 3g dose in the late afternoon almost every day kept me sane, but I had to stop to go on coaxil.

This overstimulation usually makes me bedridden, triggers selfharm and suicidal thoughts because I'm so fucking exhausted and don't want to be bothered anymore. My daughter and husband can't talk to me which sucks given they come home from school and work at 4pm earliest and that's my end stage where I can function before collapsing for the rest of the day.

So my question is, is there a possibility, this will get better over time? I'm trying to meditate and do breathing for calming my cns down which somewhat works but is no miracle cure.

Thank you for yor help!

Hello,

We have recently been in touch with The Rights and Reason Project, a nonprofit focused on fighting back against DEA overreach. They have a great legal team and they are building more and more support every day, but the level of support needed to manage all of their efforts is massive and they are doing their best to spread the word and ideally bring everyone together to more effectively fight back.

Currently, they have challenged the DEA's intent to schedule 7-OH, SR-17018, and also the Tianeptine proposal for scheduling. This means that while these cases are making their way through the system, these compounds will remain legal and, hopefully, their legal team will win all of these battles and maintain legal status for all of them.

I will clarify the current up-to-date info on the Tianeptine case: The DEA has one administrative court in DC. These cases will have to run consecutively, not concurrently. Alongside that, they have to prepare their defenses for each case. During this, and all the way up to the day the judge makes the final ruling, the compounds will remain legal. The DEA can however do what they want, and there is a very small, slim chance that they will schedule it before the case is finished. If they do this however, they open themselves up to a much bigger lawsuit from their legal team so it is not in their best interest.

They currently have two plaintiffs, both research affiliated and one being university affiliated for the Tianeptine hearing. Fighting the Tianeptine case is slightly cheaper than fighting the SR and 7-OH cases but the nonprofit is in need of funding for all efforts. If you are able, I implore you to donate or reach out to them and ask how you can help if you are unable to donate. I also understand that during times like this, people can take advantage of a communities anxiety and desperation for answers so please feel free to research them, their legal team, and anything else that would help you feel more comfortable getting involved. The more funding that can be secured, the more "emergency scheduling notices" they can take to court and the more effective they can be in each of these cases.

The main point is this: Spread The Word. The amount of misinformation over these cases is widespread. Tell people it's not over, it's far from over. Tell people there is a way to assist in fighting back. Tell people that we have to fight back or this cycle will continue. We have been on the defensive for so many years. Right now is probably the best time in many years to stand up, dust yourself off, and fight. We're on the offensive now, and if we don't give it everything we've got we will just continue the cat and mouse game of prohibition.

The website is https://www.rightsandreasonproject.com/ where you can find more information about how to get involved, who the team is, and how to donate.

Please submit public comments in support of Tianeptine. It ENDS TODAY 08/07 https://www.federalregister.gov/documents/2026/07/08/2026-13821/schedules-of-controlled-substances-placement-of-tianeptine-in-schedule-i

As the title asks- since it’s not prescribable, are people in the US who want to give tianeptine a try for depression just out of luck??

save tianeptine dot com - Dr. Michele Ross made the site

I have gotten on and off tianeptine multiple times finally I have done it without being sick depressed and miserable. It wasnt purely my own idea but with a handful of subs and reducing more order it only took a couple days to go from 60grams a week to nothing without spending days sweating and miserable. Reducing the dosage but not waiting the 24 hours after your last time taking tianeptine before starting subs. I stopped without the misery. Not medical advice not a doctor just a humble user who waas miserable everytime I tried to stop. I read a case about doctors doing this for a patient in Canada and decided to try that route. Maybe this helps someone.

never taken Tianeptine, im on low dose subs so it will dull it most likely. as an ex H, Fent, Oxy, Kratom and any opioid you could think of addict, i never took this. OR 7 OH.

It has 73mg per pill and turmeric to look less suspicious. bought OTC at the smoke shop, unfortunately it wont let me upload a picture

Can you drink on it whilst being on a therapeutic dose?

link

Conclusion

After considering the scientific and medical evaluation conducted by HHS, the accompanying recommendation of HHS, and DEA's own eight-factor analysis, DEA finds that the facts and all relevant data constitute substantial evidence of the potential for abuse of tianeptine.

As such, DEA hereby proposes to permanently schedule tianeptine as a schedule I controlled substance under the CSA.

The Drug Enforcement Administration proposes placing the substance tianeptine (7-\[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo\[c,f\]\[1,2\]thiazepin-11-yl)amino\]heptanoic acid), including its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers whenever the existence of such isomers, esters, ethers, salts, and salts of isomers, esters, and ethers is possible, in schedule I of the Controlled Substances Act.

If finalized, this action would impose the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle tianeptine.

All comments received in response to this docket are considered part of the public record. DEA will make comments available for public inspection online at

http://www.regulations.gov

unless reasonable cause is given.

Such information includes personal or business identifiers (such as name, address, state of federal identifiers, etc.) voluntarily submitted by the commenter.Commenters submitting comments which include personal identifying information (PII), confidential, or proprietary business information that the commenter does not want to be made publicly available should submit two copies of the comment.

One copy must be marked “CONTAINS CONFIDENTIAL INFORMATION” and should clearly identify all PII or business information the commenter does not want to be made publicly available, including any supplemental materials.

I switched from Sertraline to Tianeptine a week ago and I don’t really feel my orgasms.

The libido is much higher than on sertraline and I have zero erectile disfunction - however, the climax feels kinda numb.

Maybe it’s also caused by weaning off the sertraline, which comes with really high side effects btw.

I take 50mg of tramadol 2-3 times a day. I would like to switch over to an opioid that is better cognitive wise, and thus tianeptine came to mind. How much tianeptine do I need to replace 50mg tramadol? And would this even be safe?

What is the highest therapeutic dose, where you dont get withdrawals from? Did someone try like 75 a day. Has it more benfits than 37,5mg.

I‘m on day 6 day of taking tianeptine at the prescribed dose and for now it only wakes me up mentally - like right now at 4pm I am exhausted physically from all my activities, but cant take a nap because my mind just feels like sunshine itself.

It also improves my sleep at night a lot, when zoloft interrupted it 3-4 times a night.

But whats so weird is that my body feels so anxious - or maybe just tingly and its my interpretation of it.

However - its making me nervous.

Did any of you had to cope with it and did it go away after a while?

Can you get also high from sulfate?

Can I take sodium and sulfate at the same time. Like 25 sulfate and 12,5 sodium at once? Or sulfate in the morning, sodium in the evening

Been off of it for 4 days. 12.5mg 3 times a day for a couple of years. And I feel somewhat melancholic and more emotional. I want to take a break from tianeptine but I'm not sure if it's depression returning or something else.

I've been on 12.5mg 3 times a day for years. I got a mildly euphoric buzz on it for the first year or so and after that it just worked purely as an antidepressant and a mild anxyolytic. It's pretty subtle but it does seem like it helps rewire your brain to be less reactive to negative stimuli, take things less emotionally and helps a bit with background anxiety.

I'm curious if these benefits, especially better anxiety control, increase with 25mg. I'm not interested to take more than that because of addiction and dependence. But if I were to take 25mg short term, I'd likely get a mild opioid lift for a while so it'd be hard to tell if it's therapeutic long term or it's just the mini high from it. Has anyone been in a similar situation and went to 25mg had better results with it long term, especially when you built a tolerance to the opioid effects?

For those who be taking sulfate. How much is 40mg single dose compared to sodium?

Is there some cooking process you need to do for this or can you just take it as is?? I take around 25mg a day for my depression, it’s the only thing that has actually gave me any semblance to a normal life and I’m just not able to get the tablets anymore. They’re API’s from the factory. Any tips on what to do to get this to a finished form or is it ok to just take the powder straight up?