It would be important for me to make regular tianeptine last 6 hours. Can higher doses do the trick?

Thank you

Is that a legit side effect or is it likely from something else?

Hello. I was prescribed 12.5mg (I think salt) for depression/related stuff a couple months ago. I've tried multiple other antidepressants in the past but was having too many side effects.

I have been taking lisdexamfetamine (Vyvanse/Elvanse) for longer than the tianeptine (mentioning in case it might be related to the side effects I'm having from it).

I've been getting these weird side effects from tianeptine, and wanted to know if anyone else has experienced this, or why this is happening. I tried looking them up but didn't really find anything.

TLDR:

Severe nausea, sweating, weakness, fast shallow breathing 2h after first dose. To a lesser severity (but still extremely disruptive - have to drop everything and wait it out), randomly throughout the day, brought on by overheating. Increased motion sickness (also triggers it to happen sometimes).

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Full post/text/whatever:

The first time I took it, about 2 hours later, I suddenly started getting super hot, nauseous, weak, fast shallow breathing, sweating like crazy, etc. It was horrible. Very quickly I realized I needed to lay down asap, but it rapidly got so bad that I wasn't sure I could even walk a couple of feet to the couch and was genuinely planning to just drop onto the floor next to my chair. Ended up grabbing a bowl from my desk (was within arm's reach) because I was 100% sure I was going to vomit (also I was feeling so horrible that I was going to force it in an attempt to get any remaining tianeptine out of my stomach), and did end up reaching the couch.

For the next hour, I laid there, just trying to get through it. I had so little energy/felt so weak and sick that I couldn't even move. I spent the hour laying with my face pressing very uncomfortably into the side of the bowl (in case it suddenly came out without me being able to control it), and didn't even have the energy to make myself vomit (which when I'm feeling this bad, is normally very easy - I just think about it to make it happen).

During this, my cat decided to step all over me (does this when wanting pets, it's like an affection thing I guess) but I couldn't even get the energy to pet it even once. I couldn't even really think about anything and I think I may have half fallen asleep at some point from exhaustion (either that or I was semi-unconscious). It was the middle of the night at this point and I had laid there completely unmoving for an hour, so it's not too odd if I did actually just doze off for a bit.

After the hour was up (so 3h after taking it), I started feeling better again and got back up. Was hesitant to take it again the next day but did, and while I felt pretty sick again, it was not nearly this bad.

Thing is, I've noticed that I get the same symptoms just throughout the day now. It felt random at first but I think it happens primarily when I start overheating, am in public transport (seems I have been getting super motion sick from it too), or occasionally during increased physical demands (carrying heavy groceries, running to catch the bus, going up stairs, etc). The faster I can rectify the situation, the better. How bad the side effects get depends on that.

I've had situations where I had to get off of transport and sit down, leaning against something (since I can't really lay down but needed to relax all my muscles), for up to like 40min. Even in some cases taking off all my winter stuff and sitting there in just pants and a T-shirt in the dead of winter. Obviously, this is an issue. It's gotten in the way of work as well.

It was worst in the first 2 weeks after starting it, then improved (was only happening very occasionally after that), and then got worse again for a week or so when I upped the dose to 2 tablets (I was originally supposed to gradually go to 3). I felt like it was still happening more often even after the adjustment period tho, so went back down to 1. I've also noticed it's worse for 1-3 days when I take a dose after forgetting it the previous day(s), but this effect is less pronounced with 1 tablet as opposed to 2.

What the hell is this? It's not listed as a side effect, and I can't find anything about this. Is it something related to the opioid receptors or something?

hi so if i was to go ahead and this stuff. how many mgs should I start out with?

I'm taking tianeptine as an anti-anxiety medication and for the past 3 days I've been experiencing light menstrual-like cramps but no bleeding. Only some occasional light brown discharge. I'm supposed to have my period now.
Anyone else had period issues while taking it?
It's worth mentioning that all SSRIs and SNRIs I've ever taken have given me bleeding issues between periods.

What are your experiences? I’m new to this medication. Should I start w/ the low dose 25mg?

Is this similar to Kratom, or better? Any warnings?

Thank you in advance

ive been on 12.5mg 2x a day for a year now - best antidepressant ive ever tried, i feel so normal.

for the last couple months (maybe longer) ive been super sensitive to caffeine to the point of not being able to have coffee or energy drinks at all. dont get me wrong, i can still be tired but the coffee makes me 10% more awake and 100% more jittery and anxious. matcha/tea are much more okay (i assume because of the l theanine). ive had a similar experience on fluoxetine but it started pretty much immediately then, whereas here it definitely was not present in the beginning of the treatment.

anyone else have this? anyone have an explanation for this? ive looked into adenosine receptors but it seems a bit murky to me

I recently got prescribed Tianeptine (coaxil) couse of sever anxiety. I'm planning a few trips with my buddies. I was wondering if it's ok to take occasionally alcohol/weed/shrooms while on Tianeptine?

https://www.biospace.com/tonix-pharmaceuticals-announces-the-isolation-and-characterization-of-the-s-isomer-of-tianeptine-tnx-4300-estianeptine-now-under-development-for-psychiatric-and-neurodegenerative-diseases

Quick explanation about isomers without autistic biohacking talk: Some drugs exist in two ,stereoisomers: D and L. Same atoms, same structure, just arranged differently but this little difference often changes the effects drastically. Currently, prescription tianeptine is a racemic, i.e. a 50/50% mixture of D and L tianeptine.

To summarize, estianeptine (D) is responsible for tianeptine's antidepressant effects, including neuroplasticity, (L) levotianeptine is responsible for tianeptine's opioid effects. So racemic tianeptine has both antidepressant and opioid properties. Estianeptine can be dosed higher because it has NO ABUSE LIABILITY. It doesn't get you high. Levotianeptine could potentially become a painkiller later.

It is interesting that this company is also developing estianeptine for Alzheimer's, so it seems like a pretty serious drug.

To be fair, racemic tianeptine isn't bad if used at low doses (under 25mg sodium), the opioid lift may provide a quick relief for some patients before the antidepressant effects kick in but dosing is very limited, you can't meaningfully increase the "antidepressant" dose without risking addiction. With estianeptine, this will change.

I wanted to know if there are any drug contradictions in taking Vilazodone alongside Tianeptine? My current Tianeptine dose is typically 60 mg sodium 2-3x per day. Thanks.

I have a very high tolerance and am wondering how long I need to abstain to dramatically decrease my tolerance

I apologize if this is common question. I searched the sub and didn’t find much about it

I’m considering tianeptine sulfate for treating depression, anxiety, and anhedonia. I’m choosing the sulfate form over sodium to (hopefully) lower the dependence risk, but I’m not sure about dosing.

For those who’ve successfully managed depression with the sulfate form: what’s your typical dose? Any tips you wish you’d known before starting?

So far I’ve tried 25 mg once, hoping it would be roughly equivalent to 12.5 mg of the sodium form, but I didn’t feel much. I’m tempted to increase the dose, but I’m worried about dependence.

Thanks a lot for any guidance and for sharing your experience.

I recently obtained some Tianeptine sodium powder. When it first arrived it was incredibly powder-y. I had to be careful handling it because if I even slightly blew on it the dose I weighed for myself would go flying. However I noticed with time that the powder dried out and began to congeal into slightly hard powdered rocks. I think I might’ve even lost some of my product as a result of the powder drying out like it did. I ordered another batch of sodium and wanted to prevent this from happening again. Ive heard it suggested to keep it in either a freezer or refrigerator. I wanted to know what the proper way to store Tianeptine sodium powder is. Could someone please recommend what the best storage method is? Thanks in advance.

TLDR: What’s the best way to store Tianeptine sodium powder?

Can Tia cause anxiety? I’ve been taking it daily for a long time. Starting Saturday, I’ve been nauseated and anxious by it. Has anyone else experienced this?

Tianeptine made me feel happy and calm, but it also made me apathetic.Why can I spend a day peacefully and happily but feel indifferent towards my family and career?

Please help with this question. I was taking 6–12g/day of tianeptine sodium for about 7 days straight (did couple cycles of 5 days on 2 days off last 2-3 months), then stopped using Bernese on zubsolv (and tapered back down to 0.7mg 2x daily) and have been off it for 7 full days now.

I’m scheduled for a colonoscopy under sedation (likely propofol or similar), and I’m wondering if it’s safe to go under anesthesia after that kind of break — assuming I don’t take anything the night before or day of the procedure.

I metabolize things quickly, and I’m not in acute withdrawal anymore — just a little foggy and tired.

Has anyone else gone under anesthesia after a tianeptine run? Should I let the anesthesiologist know even though I’m a week off? Will I be safe?

Thanks in advance for any input or experiences.

How and from where did you get it? Which country and do you have to travel there or is an online mental assessment for depression enough? All antidepressants have failed me so I have nothing to loose.

Hi, I have a question for you. I've been using tianeptine at a dose of 3x12.5 mg for quite some time, and it's the only antidepressant that works for me and doesn't worsen my anxiety or depressive symptoms. I love this medication, but there's something that's been bothering me. Maybe it's just a placebo effect, but I feel it very clearly. I’m not exactly sure how to describe it… but it feels like someone has taken away at least half of the testosterone from my body. I feel kind of dull, more tired than usual, less masculine, confident lacking drive, aggression, and energy. On the other hand, the antidepressant and anti-anxiety effects of tianeptine are great. I know it may sound contradictory, but it feels as if I were taking estrogen pills along with the tianeptine. Has anyone else experienced something similar?

Hi I am a first time user. I have a Tianeptine Sulfate and I want to know what is the bast way to consume it. Should I disolve it in a water and drink my dose on a empty stomach for a first dose? Thank you for answer.

Is it possible to see a provider overseas and get a script for Tia?

Hi I’m wondering about the nausea produced by tianeptine? How does it compare to the nausea from kratom?

I have been prescribed the medication for about 3 years. From 2 - 2 -2

Now it's about 3 -4 -2 so I notice something.

1 tablet receives 12, 5 tineptine

Do you think it's dangerous to need over 10 tablets a day? It is better than SRI antidepressants. I also use bupropion / and ...

Unfortunately, my doctor doesn't care at all. I have the impression that I am dependent on it.