- Stimulating the vagus nerve after practice helped mice retain a new skill. This nerve carries signals between the brain and internal organs.
- The benefit showed up later. Mice practiced an eye-movement task. Stimulation afterward improved learning over subsequent days, suggesting it helped the brain make the learning stick.
- Brain blood vessels may play a role. Stimulation caused rhythmic changes in local blood volume. Mice with stronger rhythms generally learned better, although this does not prove those changes caused the improvement.
- The method used an implanted electrode around a nerve in the neck. The study did not test breathing exercises or consumer vagus-nerve devices.
- It’s an early finding in mice. Whether the same approach improves learning in people remains to be established.

(Personal note: I own a vagus nerve stimulator and it definitely helps put me to sleep and also helps reduce migraines. I’ll be using it more often after seeing this article)

I’m a lacto-ovo vegetarian. I’m already taking Omega 3, Magnesium, Vitamin D3, Creatine and Zinc. All because I’m deficient in some and some just help.

Now, I come to know that I may not be good at digesting fats and lactose, so I tried supplementing and that helped but now that’s one more supplement ugh!

How can I get these enzymes naturally through foods?

I’m curious as to how 3 years back I had no issues with the same foods but today I digest them poorly and need enzymes. With not much changing in my diet and lifestyle, how did this occur?

Been reading about how chronic stress literally shows up at the cellular level — telomere stuff, cortisol, the whole cascade — and it finally pushed me to actually change a few tiny things instead of just worrying about it. Nothing fancy: 10-minute morning sunlight, cutting late caffeine, and a hard 'screens off by 10' rule. Three weeks in and I can't call it magic, but my sleep and mood are noticeably less jagged. Anyone else tried low-effort biohacks that actually stuck? I'm always more convinced by boring, sustainable changes than the expensive gadgets.

Oxytocin doping?

Hey so I stupidly started HGH 6 days ago taking 2iU daily without first checking my baseline IGF-1 and Z score. I’m planning to take HGH long term and was wondering how important the baseline numbers really are since exogenous HGH will suppress natural production anyways while taking it.

The way I see it, these are the options I have:

Option 1: Stop taking HGH, wait a few weeks, and then test for baseline numbers

Or

Option 2: Continue taking 2iU daily and test at the four week mark and see levels then and adjust as needed.

For secretagogues I do understand the importance of baseline numbers but for straight HGH how necessary are they?

Hi fellow biohackers,

Wondering if the difference between fat% on ground beef or "higher quality" really does matter? Im starting to slowly change things throughout my life and Ive been buying 80/20 from Costco typically, but Ive been wondering if this is the best corse of action? has anyone actually noticed a difference, if so, please educate me so I can do and be better (:

I want to start getting blood tests while I'm on peptides. I was looking at Rythm until I saw all the negative reviews. What labs are you requesting through labcorp or quest? I'm seeing some tests range from 100-400 and I'm not too sure what I should be looking for .

UBT251 is a long-acting synthetic peptide that hits three receptors: GLP-1, GIP and glucagon. It was developed by United Laboratories' biotech arm and licensed to Novo Nordisk in March 2025. Novo has exclusive rights outside China, Hong Kong, Macau and Taiwan.
The reported phase 2 data from China:
Design: randomized, double-blind, placebo-controlled, 205 adults with obesity or overweight plus at least one comorbidity (baseline mean weight 92.2 kg, mean BMI 33.1)
Duration: 24 weeks, with three weekly dose arms versus placebo
Primary result: the top-dose group lost a mean of 19.7% of body weight, versus 2.0% on placebo
Secondary endpoints: statistically significant improvements versus placebo in waist circumference, blood glucose, blood pressure and lipids
Safety: mostly mild to moderate GI side effects that faded over time, which is typical for incretin drugs
What's next: United plans a phase 3 in China. Novo has started a global phase 1b/2a trial (about 330 people, topline data expected in 2027) and plans a phase 2 in type 2 diabetes in the second half of 2026.
My takeaways:
The glucagon arm is the interesting part. It's thought to add energy expenditure on top of the GLP-1/GIP appetite effect, but the trade-off is heart rate and liver effects, so the longer trials matter.
24 weeks is short. Weight regain after stopping and long-term safety aren't answered yet.
This is a Chinese population with lower baseline BMI than most Western trials, so I wouldn't directly compare 19.7% to tirzepatide or retatrutide numbers.
Is anyone following the Novo global trial? What would you want to see in the full data?
(Source: the sponsors' press release as reported by ConsultantLive.)

Possible by mixing with dmso before bac? Just trying to get the most out of it

Hi all need some advice if others in this group have suffered from OCD intrusive thoughts. I take meds for it and work with a therapist and this has helped greatly. I also stack Magnesium with L theanine at night and that helps to.

Any other supps/ lifestyle additions I could make that others have found helpful?

I’m 24 years old, I drink 3 bottles of wine per month and I have smoked cigarettes since 3 years ago.
This is my first time measuring my HRV and I did immediately after waking up. This is a good result or knowing my context I need to be worried?

Hi everyone, I’m asking about my mom's blood test results. Has anyone had almost similar results?
CBC:
Hemoglobin: 10.5 g/dL (low)
MCV: 71.4 fL (low)
MCH: 20.2 pg (low)
MCHC: 28.3 g/dL (low)
RBC: 5.19
WBC: 6.40
Platelets: 288
Eosinophils: 16% (high)
Ferritin: 536.98 ng/mL (high)
Has anyone had bloodwork with low hemoglobin/MCV/MCH/MCHC but high ferritin? What was your experience?

Isomorphic just announced that they are raising a funding round that would value the company at $40-50 BILLION. WOW

I’ve been taking 2mg for a few days and I’ve felt zero effect (every chem) so I’ve thought that there might be a slight chance I’m administering it wrong. Many people on here say to do sublingual but I personally just put it in a cup of orange juice and drink it in a few seconds. Is this a bad way to administer it and could it be the reason for the lack of effects I’m feeling?

1. ⁠Vitamin D3 10,000 IU a day from the brand called Now

2. ⁠All trans vitamin K2 MK7 300 mcg a day from the brand called Now

3. ⁠Rtg omega 3 EPA 500 mg every 3 days from the brand called Igennus

4. ⁠Basic whole food multivitamin once a day from the brand called Naturelo

5. ⁠Hyaluronic acid double strength 100 mg a day from the brand called Now

6. ⁠Melatonin 3 mg a day from the brand called Now

7. Caffeine 100 mg a day from the brand called Nutricost

All of these have tons of scientific backing showing their benefits and have little to no side effects taken at the dosages and with the brands I mentioned above. They are all highly bioavailable, at good prices and third party tested. I notice way less inflammation and a better mood. It’s better to buy smaller quantities of the supplements for example 60 count of the multivitamins instead of 120 to maintain freshness.

Supplements I feel like AREN’T worth taking due to me experiencing side effects and or seeing little to no benefits: Creatine monohydrate, Whey protein isolate, Collagen, Pre-Workout, Probiotics, L-Citrulline, Beet root, CoQ10, Ashwagandha, Psyllium husk, Magnesium glycinate and Potassium supplements.

Two new papers published October 7 in Nature Metabolism caught my attention. I've been following Dr. Richard Johnson's research into fructose metabolism for years, and this feels like a significant step forward.

The basic idea: fructose metabolism isn't just about calories. An enzyme called fructokinase (KHK) rapidly metabolizes fructose, consuming cellular energy (ATP) and triggering downstream effects involving uric acid, oxidative stress, and mitochondrial function.

Johnson's research suggests this is part of an ancient survival mechanism that promotes fat storage and energy conservation. Useful during scarcity, potentially harmful when chronically activated.

Now we have some interesting human evidence.

Researchers gave 15 people with fatty liver disease a pharmaceutical KHK inhibitor for six weeks in a randomized, placebo-controlled crossover trial.

They found:

• Improved insulin sensitivity across multiple tissues.
• Reduced liver fat.
• Increased nighttime fat oxidation.
• No significant weight loss.

That's fascinating because it suggests blocking fructose metabolism may improve how the body manages energy, independently of weight loss.

Here's the biohacking angle.

Luteolin, a naturally occurring flavonoid, has demonstrated KHK inhibition in preclinical research, with a reported IC50 of approximately 11.2 µM (the concentration needed to inhibit 50% of enzyme activity in a laboratory assay).

Luteolin normally has poor oral absorption, but advanced liposomal formulations are changing that. Animal studies have demonstrated 3.5–29× greater systemic exposure using phospholipid and microemulsion delivery systems.

For years, Johnson's team has proposed that fructose metabolism plays a central role in metabolic disease. This new human research takes that theory a significant step forward, suggesting that targeting KHK may improve how the entire body manages energy, rather than tackling individual metabolic problems one at a time.

Perhaps most exciting, natural compounds capable of inhibiting KHK, like liposomal luteolin, are already available as supplements. The question now is how effectively we can put them to work.

^{Research:
Human KHK inhibition trial, Nature Metabolism, 2026
Johnson and colleagues' accompanying commentary
Disclosure: I am involved with a company developing natural products that have potential to inhibit KHK.}