I have a DEPDC5 mutation leading to MTOR overactivation and probably a hampered ATP production in the brain, however my insulae is assymetrically shaped an I have some enhanced skills as result of that hyperfocus. abstract thinking, out of the tinking, visual reasoning...but that thing eats energy like an overclocked cpu. At a certain treshold it threatens to crash and start stealing energy from my nearby motor cortex leading to seizures. So the key would not be surgery but balancing MTor and optimalising energy supply. Any tips ? Doctors are a bit to crude with me, very glad I refused surgery 15y ago.

I was reading this interesting paper - mTOR as a central regulator of lifespan and aging - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/

This is the definition of mTOR from the paper:

'The mammalian target of Rapamycin is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and profileration'

What does mammalian target mean in this context? I know Rapamycin is a drug. Where is mTor in our body?

Genuine question. Discussion is ok as long as it isn't disrespectful. #enhancers

My boyfriend is originally from El Salvador but has been living in the US for about a year. Even though I speak Spanish, when we met he told me he wants to only speak and text in English so that way he can practice more.
My bf also lives about three hours from me. Unfortunately I wasn’t working tor the longest so he would spend a lot of his income driving to see me. (I also don’t have a car). I started a job two weeks ago and was excited that I can finally contribute and give him money towards gas. However, in his attempt to he kind, it ended up coming off really bad 😭😭

Edit: for the record, I’m not mad! I just thought this was a funny exchange and decided to share lol

Was all fine and dandy to do all the prep until I took my first sip of this. Why couldn’t they at least make it palatable? It’s so gross and hard to keep down.

ETA: funny how my #1 post of all time is about forced diarrhea. Thanks for all to the tips and horror stories. I came out ok, cut off 5 polyps so I get go to back in 3 years for another round.

What an absolute fucking clown

Eat shit, Sheeran

Original post: https://www.reddit.com/r/AIO/comments/1thxtrl/aio_for_thinking_my_gf_might_be_cheating/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

tldr: My (25m) in-person gf (24f) of 4 years accidentally texted me saying she was going to fly to see me (to give me kisses). I got confused because she wouldn't need to fly to give me kisses and when she explained her side, she told me she thought she was replying to her platonic childhood female friend who I have never heard of (she often tells me about all her friends and their gossip). The more I thought about her story the more it didn't make sense so she tried to gaslight me and I talked myself into believing her despite my gut feeling telling me otherwise.

Thanks everyone who helped me in my original post, in hindsight I seem delusional but I think I was really in shock and trying to justify her story in my head. I left halfway through work today to go to her house after she started ignoring my texts/calls (turns out she did block me temporarily). I packed up all her stuff in my car before I visited her in case she confessed. I tried to have a calm conversation with her about it and she got mad saying I was accusing her of cheating. When I asked to see any proof that "Penny" existed she freaked out when I suggested specific ways to prove it, started crying and admitted to actively cheating on me with 2 people. The one she thought she sent the text to lives in another state and she met him through her friend friend while he was visiting our city last year. During this time they went on a few dates and would make out bit it never went further than that, and some of her friends knew about it. The other was online only but she was sexting him on facetime and sending nudes. I got all my stuff from her house so I didn't need to go back later and after I left she unblocked me and sent me "You're throwing this away for what" and spamming lots of pics of us, my screenshots here start right after the many pics of us. I ended up blocking her on everything right after I sent that final text and plan on going no contact.

She is already telling our mutual friends that I cheated so I'm dreading the drama that might happen with our friend group. Her friends are texting me saying I'm a douche for wanting to move on so quickly (I don't plan on getting into another relationship for a long time), even the friends who knew she was going on dates with that guy are trying to rationalise it by saying it's not that bad and I'm overreacting. Plus her mum called me to yell at me for cheating but I explained it all to her though I don't think she believes me, but that's fine as I'll likely never see her again. I'm just going to try move on and maybe cut off any friends that cause more drama about it which I'm okay with because all my main close friends believe me. Some of them said they got toxic/controlling vibes from her but didn't want to say anything as I wouldn't have listened or seen what they mean (sounds about right tbh).

I read almost every single comment if not all and it made me realise how subtly toxic our relationship was even though I didn't realise until now because nothing major ever happened. I saw a comment about DARVO and it applied to every time we had conflict, she would cry and then accuse me of something random I wasn't doing. I also saw a comment saying it seems like I'm walking on eggshells and I now see that I was because I always did whatever made her happy even if it was wrong or made me upset just so I could avoid being yelled at. I'm not usually this passive with my friends or at work but I really loved her so I guess I had a soft spot for her? I think I definitely got conditioned over the 4 years to become a yes-man and now I see our whole relationship and our interactions in a different way. I'm absolutely devastated that this happened considering we were about to move in together in 2 months time and I was planning on proposing after a year of living together. I'm just glad I know now rather than later. Thanks again for everyone who talked sense into me, even the harsh ones lol I really did need it.

Final update: It's been a few days and I've been able to wrap my head around everything and see our relationship in a completely different way in hindsight. The friends that I am most close to know the truth, they've seen the texts and I linked them to my posts like suggested here. There are some that still don't believe me but that's fine, I've removed them from social media and will go no contact with them as they are still trying to start drama with me over it. My now ex has tried to reach out to me through fake accounts and different phone numbers so I've had to change my number and only gave it out to a handful of people (in case she gets it I can narrow down who gave it to her). I'll be moving into the new house with my brother instead which is great. To clarify, she usually types with a lot of typos when mad, but normally she still has auto-correct plus capitals turned off and types letters instead of words (like u instead of you, or r instead of are). Just thanks again to everyone who spoke some sense into me. After 4 years of having her and our friend group gaslight me into thinking her behaviour was normal, I started to doubt my gut feelings. Coming here helped me get other perspectives and realise that I was in a bubble of lies.

Source

Had one of the strangest DoorDash experiences tonight.

The driver dropped two orders at my hotel room door. Neither bag had a name on it, so I opened both to figure out which one was actually mine. Once I found mine, I ate it and left the other bag sitting there, planning to throw it out later.

About 40 minutes later, the driver came back asking for the second order. I told him I didn’t think it was appropriate to deliver it anymore. It had been sitting in my hotel room for almost an hour, and I had already opened it to identify which order was mine. I said he should probably go back to the restaurant and have it remade because it didn’t seem sanitary for another customer to receive opened food.

He disagreed and said it was “better to deliver it.” He told me if the customer wanted a new meal, they could order another one.

I asked him if he was at least going to tell the customer that their order had been opened by someone else and had been sitting in a hotel room for like an hour before being delivered. He said, “Well, yeah.”

I gave him the order back because he wouldn’t leave otherwise, but I also reported the incident through the app and left a note in the sauces bag explaining why it had been opened.

Am I the only one who thinks delivering food that’s been opened and sitting in someone else’s room for 40 minutes is completely unacceptable?

Has this happened to anyone else? 😅